Department of Psychology, York Neuroimaging Centre, York Biomedical Research Institute, University of York, United Kingdom.
CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Brain Lang. 2024 Apr;251:105402. doi: 10.1016/j.bandl.2024.105402. Epub 2024 Mar 13.
Recent work has focussed on how patterns of functional change within the temporal lobe relate to whole-brain dimensions of intrinsic connectivity variation (Margulies et al., 2016). We examined two such 'connectivity gradients' reflecting the separation of (i) unimodal versus heteromodal and (ii) visual versus auditory-motor cortex, examining visually presented verbal associative and feature judgments, plus picture-based context and emotion generation. Functional responses along the first dimension sometimes showed graded change between modality-tuned and heteromodal cortex (in the verbal matching task), and other times showed sharp functional transitions, with deactivation at the extremes and activation in the middle of this gradient (internal generation). The second gradient revealed more visual than auditory-motor activation, regardless of content (associative, feature, context, emotion) or task process (matching/generation). We also uncovered subtle differences across each gradient for content type, which predominantly manifested as differences in relative magnitude of activation or deactivation.
最近的研究集中在颞叶内功能变化模式如何与全脑内在连接变异性的整体脑维度相关（Margulies 等人，2016 年）。我们检查了两种这样的“连接梯度”，反映了（i）单模态与多模态和（ii）视觉与听觉-运动皮层的分离，检查了视觉呈现的言语联想和特征判断，以及基于图片的上下文和情绪生成。第一个维度上的功能反应在模式调谐和多模态皮层之间有时表现出渐变变化（在言语匹配任务中），而在其他时候则表现出明显的功能转换，在该梯度的两端出现失活，中间出现激活（内部生成）。第二个梯度显示出更多的视觉激活，而不是听觉-运动激活，无论内容（联想、特征、上下文、情绪）或任务过程（匹配/生成）如何。我们还在每个梯度上发现了内容类型的细微差异，这些差异主要表现为激活或失活的相对幅度的差异。
