Baek Seungjin, Kim Ye-Jee, Kim Beom-Jun, Hong Namki
Department of Internal Medicine, Endocrine Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
J Bone Metab. 2024 Feb;31(1):31-39. doi: 10.11005/jbm.2024.31.1.31. Epub 2024 Feb 29.
The coronavirus disease 2019 (COVID-19) pandemic and the consequent social distancing period are thought to have influenced the incidence of osteoporotic fracture in various ways, but the exact changes have not yet been well elucidated. The purpose of this study was to investigate the impact of the COVID-19 pandemic on the incidence of osteoporotic fracture using a nationwide cohort.
The monthly incidence rates of vertebral; hip; and non-vertebral, non-hip fractures were collected from a nationwide database of the Korean National Health Insurance Review and Assessment from July 2016 to June 2021. Segmented regression models were used to assess the change in levels and trends in the monthly incidence of osteoporotic fractures.
There was a step decrease in the incidence of vertebral fractures for both males (6.181 per 100,000, P=0.002) and females (19.299 per 100,000, P=0.006). However, there was a negative trend in the incidence of hip fracture among both males (-0.023 per 100,000 per month, P=0.023) and females (-0.032 per 100,000 per month, P=0.019). No impact of COVID-19-related social distancing was noted.
In conclusion, during the early days of the COVID-19 pandemic, vertebral fracture incidence considerably decreased with the implementation of social distancing measures.
2019年冠状病毒病（COVID-19）大流行及随之而来的社交隔离期被认为以多种方式影响了骨质疏松性骨折的发生率，但确切变化尚未得到充分阐明。本研究旨在利用全国性队列调查COVID-19大流行对骨质疏松性骨折发生率的影响。
收集2016年7月至2021年6月韩国国民健康保险审查与评估全国数据库中椎体、髋部以及非椎体、非髋部骨折的月度发生率。采用分段回归模型评估骨质疏松性骨折月度发生率的水平和趋势变化。
男性（每10万人6.181例，P = 0.002）和女性（每10万人19.299例，P = 0.006）的椎体骨折发生率均出现阶梯式下降。然而，男性（每月每10万人-0.023例，P = 0.023）和女性（每月每10万人-0.032例，P = 0.019）的髋部骨折发生率呈负趋势。未发现与COVID-19相关的社交隔离有影响。
总之，在COVID-19大流行初期，随着社交隔离措施的实施，椎体骨折发生率大幅下降。
