• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

脂多糖引发的免疫耐受减轻了脂多糖刺激的小胶质细胞激活和小鼠的社交回避行为。

LPS priming-induced immune tolerance mitigates LPS-stimulated microglial activation and social avoidance behaviors in mice.

机构信息

Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.

Department of Neurosurgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.

出版信息

J Pharmacol Sci. 2024 Apr;154(4):225-235. doi: 10.1016/j.jphs.2024.02.006. Epub 2024 Feb 10.

DOI:10.1016/j.jphs.2024.02.006
PMID:38485340
Abstract

In this study, we investigated the regulatory mechanisms underlying the effects of LPS tolerance on the inflammatory homeostasis of immune cells. LPS priming-induced immune tolerance downregulated cyclooxygenase-2, and lowered the production of prostaglandin-E in microglial cells. In addition, LPS tolerance downregulated the expression of suppressor of cytokine signaling 3, and inducible nitric oxide synthase/nitric oxide; suppressed the LPS-mediated induction of tumor necrosis factor-α, interleukin (IL)-6, and IL-1; and reduced reactive oxygen species production in microglial cells. LPS stimulation increased the levels of the adaptive response-related proteins heme oxygenase-1 and superoxide dismutase 2, and the levels of heme oxygenase-1 (HO-1) enhanced after LPS priming. Systemic administration of low-dose LPS (0.5 mg/kg) to mice for 4 consecutive days attenuated high-dose LPS (5 mg/kg)-induced inflammatory response, microglial activation, and proinflammatory cytokine expression. Moreover, repeated exposure to low-dose LPS suppressed the recruitment of peripheral monocytes or macrophages to brain regions and downregulated the expression of proinflammatory cytokines. Notably, LPS-induced social avoidance behaviors in mice were mitigated by immune tolerance. In conclusion, immune tolerance may reduce proinflammatory cytokine expression and reactive oxygen species production. Our findings provide insights into the effects of endotoxin tolerance on innate immune cells and social behaviors.

摘要

在这项研究中,我们研究了 LPS 耐受对免疫细胞炎症平衡的影响的调节机制。LPS 引发的免疫耐受下调环氧化酶-2 的表达,并降低小胶质细胞中环前列腺素 E 的产生。此外,LPS 耐受下调细胞因子信号转导抑制因子 3 和诱导型一氧化氮合酶/一氧化氮的表达;抑制 LPS 介导的肿瘤坏死因子-α、白细胞介素 (IL)-6 和 IL-1 的诱导;并减少小胶质细胞中活性氧的产生。LPS 刺激增加适应性反应相关蛋白血红素加氧酶-1 和超氧化物歧化酶 2 的水平,并且 LPS 引发后血红素加氧酶-1(HO-1)的水平增强。连续 4 天给小鼠系统给予低剂量 LPS(0.5mg/kg)可减弱高剂量 LPS(5mg/kg)引起的炎症反应、小胶质细胞激活和促炎细胞因子表达。此外,反复暴露于低剂量 LPS 可抑制外周单核细胞或巨噬细胞向脑区的募集,并下调促炎细胞因子的表达。值得注意的是,免疫耐受减轻了 LPS 诱导的小鼠社交回避行为。总之,免疫耐受可能会降低促炎细胞因子的表达和活性氧的产生。我们的研究结果为内毒素耐受对固有免疫细胞和社交行为的影响提供了新的见解。

相似文献

1
LPS priming-induced immune tolerance mitigates LPS-stimulated microglial activation and social avoidance behaviors in mice.脂多糖引发的免疫耐受减轻了脂多糖刺激的小胶质细胞激活和小鼠的社交回避行为。
J Pharmacol Sci. 2024 Apr;154(4):225-235. doi: 10.1016/j.jphs.2024.02.006. Epub 2024 Feb 10.
2
Morin downregulates nitric oxide and prostaglandin E2 production in LPS-stimulated BV2 microglial cells by suppressing NF-κB activity and activating HO-1 induction.莫林通过抑制 NF-κB 活性和激活 HO-1 诱导来下调 LPS 刺激的 BV2 小胶质细胞中一氧化氮和前列腺素 E2 的产生。
Environ Toxicol Pharmacol. 2016 Jun;44:62-8. doi: 10.1016/j.etap.2016.04.010. Epub 2016 Apr 22.
3
Antagonistic effects of acetylshikonin on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1.乙酰紫草素通过抑制 ROS/PI3K/Akt 介导的 NF-κB 信号通路和激活 Nrf2 依赖性 HO-1 抑制 LPS 诱导的 BV2 小胶质细胞中 NO 和 PGE2 的产生的拮抗作用。
In Vitro Cell Dev Biol Anim. 2015 Oct;51(9):975-86. doi: 10.1007/s11626-015-9922-y. Epub 2015 Jun 20.
4
New compound, 5-O-isoferuloyl-2-deoxy-D-ribono-γ-lacton from Clematis mandshurica: Anti-inflammatory effects in lipopolysaccharide-stimulated BV2 microglial cells.来自东北铁线莲的新化合物5-O-异阿魏酰基-2-脱氧-D-核糖-γ-内酯:对脂多糖刺激的BV2小胶质细胞的抗炎作用
Int Immunopharmacol. 2015 Jan;24(1):14-23. doi: 10.1016/j.intimp.2014.10.030. Epub 2014 Nov 8.
5
Manganese potentiates LPS-induced heme-oxygenase 1 in microglia but not dopaminergic cells: role in controlling microglial hydrogen peroxide and inflammatory cytokine output.锰增强脂多糖诱导的小胶质细胞血红素加氧酶 1,但不增强多巴胺能细胞:在控制小胶质细胞过氧化氢和炎症细胞因子产生中的作用。
Neurotoxicology. 2011 Dec;32(6):683-92. doi: 10.1016/j.neuro.2011.09.002. Epub 2011 Sep 25.
6
Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS.脂氧素 C 通过下调 NF-κB 并激活 Nrf2 介导的 HO-1 抑制 LPS 诱导的 BV2 小胶质细胞中 NO 的产生发挥抗炎作用。
Molecules. 2019 Sep 12;24(18):3317. doi: 10.3390/molecules24183317.
7
Lutein suppresses inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2 microglia.叶黄素通过激活核因子E2相关因子2(Nrf2)和使脂多糖刺激的BV-2小胶质细胞中的核因子κB(NF-κB)失活来抑制炎症反应。
Mol Nutr Food Res. 2015 Sep;59(9):1663-73. doi: 10.1002/mnfr.201500109. Epub 2015 Jun 23.
8
Hispolon Suppresses LPS- or LTA-Induced iNOS/NO Production and Apoptosis in BV-2 Microglial Cells.褐藻寡糖通过抑制 LPS 或 LTA 诱导的 BV-2 小胶质细胞中 iNOS/NO 的产生和凋亡。
Am J Chin Med. 2017;45(8):1649-1666. doi: 10.1142/S0192415X17500896. Epub 2017 Nov 9.
9
Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway.绣球酚通过抑制NF-κB通路和激活Nrf2介导的HO-1通路,抑制脂多糖诱导的BV2小胶质细胞中一氧化氮的产生。
Int Immunopharmacol. 2016 Jun;35:61-69. doi: 10.1016/j.intimp.2016.03.022. Epub 2016 Mar 28.
10
Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide.长期高糖环境对脂多糖刺激的巨噬细胞促炎反应的影响。
Naunyn Schmiedebergs Arch Pharmacol. 2021 Oct;394(10):2129-2139. doi: 10.1007/s00210-021-02137-8. Epub 2021 Aug 17.

引用本文的文献

1
Comparison and Assessment of Anti-Inflammatory and Antioxidant Capacity Between EGCG and Phosphatidylcholine-Encapsulated EGCG.表没食子儿茶素没食子酸酯(EGCG)与磷脂酰胆碱包封的EGCG抗炎和抗氧化能力的比较与评估
J Cosmet Dermatol. 2025 Jan;24(1):e16628. doi: 10.1111/jocd.16628. Epub 2024 Oct 31.
2
PI3K/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives.PI3K/AKT信号传导与缺血性中风中的神经保护:分子机制与治疗前景
Neural Regen Res. 2025 Oct 1;20(10):2758-2775. doi: 10.4103/NRR.NRR-D-24-00568. Epub 2024 Oct 22.
3
Repetitive Administration of Low-Dose Lipopolysaccharide Improves Repeated Social Defeat Stress-Induced Behavioral Abnormalities and Aberrant Immune Response.
重复给予低剂量脂多糖可改善重复社交挫败应激引起的行为异常和免疫反应异常。
J Neuroimmune Pharmacol. 2024 Jul 27;19(1):38. doi: 10.1007/s11481-024-10141-x.