Xu Lei, Zhang Jiaying, Dong Jinfeng, Chen Qiaobin, Ma Shurong, Jiang Jiangqi, Zheng Yiming, Zhuo Wenyu, Tang Xuan, Gao Yang, Li Xuan, Yang Fang, You Guoping, Lv Haitao, Huang Hongbiao
Department of Pediatrics, Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Pediatric, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Heliyon. 2024 Mar 4;10(5):e27290. doi: 10.1016/j.heliyon.2024.e27290. eCollection 2024 Mar 15.
To analyse the research history, development trends and current status of relevant literature in the field of Kawasaki disease, and to provide the basis for future directions in Kawasaki disease (KD) research.
Literature on Kawasaki disease published between January 1974 and December 2022 was searched for in the Web of Science database, and CiteSpace was used to perform visual analyses.
The search yielded a total of 6950 articles. The number of publications related to Kawasaki disease showed an increasing trend. A collaborative network analysis revealed that the United States, Japan and mainland China were the most influential countries in this field. The University of California system contributed the most publications and the journal with the most publications was . JW Newburger was an authoritative author in this field. "Coronary artery lesion", "Intravenous immunoglobulin" (IVIG) and "Risk factor" were three prominent keywords. Keyword bursts changed from "TNF" and "IVIG", which focused on aetiology and treatment, to "Long term management", which emphasized the recovery period, and to "Kawasaki-like disease" and "Multisystem inflammatory syndrome" during the novel coronavirus pandemic. Trends of highly cited references indicated that landmark articles in different periods focused on Kawasaki disease guidelines, gene polymorphisms and multisystem inflammatory syndrome caused by the novel coronavirus.
The aetiology of Kawasaki disease remains unclear, but viral infection is likely to play an important role. The combination of evolving sequencing technologies, large-scale epidemiological investigations and prospective cohort studies is likely to be important in exploring Kawasaki disease and improving its prognosis in future.
分析川崎病领域相关文献的研究历史、发展趋势及现状，为川崎病（KD）研究的未来方向提供依据。
在科学网数据库中检索1974年1月至2022年12月发表的关于川崎病的文献，并使用CiteSpace进行可视化分析。
共检索到6950篇文章。与川崎病相关的出版物数量呈上升趋势。合作网络分析显示，美国、日本和中国大陆是该领域最具影响力的国家。加利福尼亚大学系统发表的文章最多，发表文章最多的期刊是 。JW Newburger是该领域的权威作者。“冠状动脉病变”、“静脉注射免疫球蛋白”（IVIG）和“危险因素”是三个突出的关键词。关键词突现从关注病因和治疗的“TNF”和“IVIG”，转变为强调恢复期的“长期管理”，在新型冠状病毒大流行期间转变为“川崎样疾病”和“多系统炎症综合征”。高被引参考文献趋势表明，不同时期的标志性文章聚焦于川崎病指南、基因多态性以及新型冠状病毒引起的多系统炎症综合征。
川崎病的病因仍不明确，但病毒感染可能起重要作用。不断发展的测序技术、大规模流行病学调查和前瞻性队列研究相结合，可能对未来探索川崎病及改善其预后具有重要意义。
