Sideri Anna Maria, Mitsopoulou Dimitra, Kandarakis Stylianos A, Katsimpris Andreas, Kanakis Menelaos, Karamaounas Aristotelis, Brouzas Dimitrios, Petrou Petros, Papakonstantinou Evangelia, Droutsas Konstantinos, Giannopoulos Georgios, Georgalas Ilias
First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Ophthalmology, Princess Alexandra Eye Pavilion, Edinburgh, GBR.
Cureus. 2024 Feb 13;16(2):e54121. doi: 10.7759/cureus.54121. eCollection 2024 Feb.
We conducted a systematic review and meta-analysis to assess the association between optical coherence tomography angiography (OCTA) parameters and acute coronary syndrome (ACS). Two independent reviewers searched the electronic databases (MEDLINE (Medical Literature Analysis and Retrieval System Online), Scopus, Embase (Excerpta Medica Database), Cochrane Library, ClinicalTrials.gov, and World Health Organization International Clinical Trials Registry Platform) from inception until April 2023. According to the inclusion criteria of this review, eligible were observational studies, randomized control trials, and registry/database studies that included the eyes of adult ACS patients and assessed OCTA parameters within the macula. The pooled standardized mean differences (SMD) between patients diagnosed with ACS and healthy controls with a confidence interval (CI) of 95% were calculated using the Hartung-Knapp-Sidik-Jonkman random-effects method. The heterogeneity was assessed by I and the Cochran Q and a random effects model was applied. Seven studies were eligible and included in our systematic review (n = 898), of which three were included in the meta-analysis (n = 341). The pooled SMD in the superficial vascular plexus (SVP), deep vascular plexus (DVP), and foveal avascular zone (FAZ) were -0.46 (95% CI: -0.94 to 0.01, p = 0.05, I = 0%, three studies), -0.10 (95% CI: -3.20 to 3.00, p = 0.75, I = 67%, two studies), and 0.43 (95% CI: -1.22 to 2.09, p = 0.38, I = 92%, three studies), respectively. Our findings suggest that there are no differences in OCTA metrics between ACS patients and healthy individuals.
我们进行了一项系统评价和荟萃分析，以评估光学相干断层扫描血管造影（OCTA）参数与急性冠状动脉综合征（ACS）之间的关联。两名独立评审员检索了电子数据库（MEDLINE（医学文献分析与检索系统在线）、Scopus、Embase（医学文摘数据库）、Cochrane图书馆、ClinicalTrials.gov和世界卫生组织国际临床试验注册平台），检索时间从数据库建立至2023年4月。根据本评价的纳入标准，符合条件的是观察性研究、随机对照试验以及注册/数据库研究，这些研究纳入了成年ACS患者的眼部，并评估了黄斑区内的OCTA参数。采用Hartung-Knapp-Sidik-Jonkman随机效应方法计算诊断为ACS的患者与健康对照之间的合并标准化均数差（SMD），其95%置信区间（CI）。通过I²和Cochrane Q评估异质性，并应用随机效应模型。七项研究符合条件并纳入我们的系统评价（n = 898），其中三项纳入荟萃分析（n = 341）。浅表血管丛（SVP）、深部血管丛（DVP）和黄斑无血管区（FAZ）的合并SMD分别为-0.46（95%CI：-0.94至0.01，p = 0.05，I² = 0%，三项研究）、-0.10（95%CI：-3.20至3.00，p = 0.75，I² = 67%，两项研究）和0.43（95%CI：-1.22至2.09，p = 0.38，I² = 92%，三项研究）。我们的研究结果表明，ACS患者与健康个体之间的OCTA指标没有差异。
