First Ophthalmology Department, "G.Gennimatas" Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Department of Respiratory Medicine, University Hospital of Patras, Patras, Greece.
Eye (Lond). 2023 Oct;37(14):2847-2854. doi: 10.1038/s41433-023-02438-7. Epub 2023 Feb 14.
To examine the association between optical coherence tomography angiography (OCTA) retinal measurements and Parkinson's disease (PD).
We searched MEDLINE and EMBASE from inception up to November 5th, 2021 for studies examining the differences between OCTA retinal measurements in PD patients and healthy controls. We used the Hartung-Knapp-Sidik-Jonkman random-effects method to combine study-specific standardized mean differences (SMD) in pooled effect estimates and a meta-analytic extension of the E-value metric to quantify the confounding bias capable of nullifying the pooled estimates.
Nine eligible studies for our systematic review were identified through our search strategy. The pooled SMD between the retinal vessel density of PD patients and healthy participants in the whole superficial vascular plexus (SVP), foveal SVP, parafoveal SVP and foveal avascular zone (FAZ) was -0.68 (95% CI: -1.18 to -0.17, p value = 0.02, n = 7 studies), -0.14 (95% CI: -0.88 to 0.59, p value = 0.62, n = 5 studies), -0.59 (95% CI: -1.41 to 0.23, p value = 0.12, n = 5 studies) and -0.20 (95% CI: -0.79 to 0.38, p value = 0.39, n = 5 studies), respectively. An unmeasured confounder would need to be associated with a 3.01-fold, 1.54-fold, 2.81-fold and 1.70-fold increase in the risk of PD and OCTA retinal measurements, in order for the pooled SMD estimate of vessel density in whole SVP, parafoveal SVP and FAZ, respectively, to be nullified.
Our results provide evidence on an inverse association between whole SVP vessel density and PD.
研究光学相干断层扫描血管造影 (OCTA) 视网膜测量值与帕金森病 (PD) 之间的关系。
我们从 MEDLINE 和 EMBASE 数据库中检索了从成立到 2021 年 11 月 5 日的研究，以研究 PD 患者和健康对照者之间的 OCTA 视网膜测量值的差异。我们使用 Hartung-Knapp-Sidik-Jonkman 随机效应方法来组合研究特异性标准化均数差值 (SMD) 的汇总效应估计值，并使用 E 值度量的元分析扩展来量化能够使汇总估计值无效的混杂偏差。
通过我们的搜索策略，确定了九项符合我们系统综述标准的研究。在整个浅层血管丛 (SVP)、中心凹 SVP、旁中心凹 SVP 和中心凹无血管区 (FAZ) 中，PD 患者的视网膜血管密度与健康参与者的 SMD 为 -0.68(95%CI：-1.18 至-0.17，p 值=0.02，n=7 项研究)、-0.14(95%CI：-0.88 至 0.59，p 值=0.62，n=5 项研究)、-0.59(95%CI：-1.41 至 0.23，p 值=0.12，n=5 项研究)和-0.20(95%CI：-0.79 至 0.38，p 值=0.39，n=5 项研究)。未测量的混杂因素需要与 PD 和 OCTA 视网膜测量值的风险分别增加 3.01 倍、1.54 倍、2.81 倍和 1.70 倍相关，才能使整个 SVP、旁中心凹 SVP 和 FAZ 的 SMD 估计值无效。
我们的研究结果表明，整个 SVP 血管密度与 PD 之间存在负相关关系。
