• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫功能对骨折愈合的局部和全身影响。

The local and systemic effects of immune function on fracture healing.

作者信息

Evans Andrew R, Giannoudis Peter V, Leucht Philip, McKinley Todd O, Gaski Greg E, Frey Katherine P, Wenke Joseph C, Lee Christopher

机构信息

Warren Alpert School of Medicine at Brown University, University Orthopedics, Inc, Providence, RI.

Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds General Infirmary, Clarendon Wing, Level D, Leeds, West Yorkshire, United Kingdom.

出版信息

OTA Int. 2024 Mar 11;7(2 Suppl):e328. doi: 10.1097/OI9.0000000000000328. eCollection 2024 Mar.

DOI:10.1097/OI9.0000000000000328
PMID:38487403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10936162/
Abstract

The immune system plays an integral role in the regulation of cellular processes responsible for fracture healing. Local and systemic influences on fracture healing correlate in many ways with fracture-related outcomes, including soft tissue healing quality and fracture union rates. Impaired soft tissue healing, restricted perfusion of a fracture site, and infection also in turn affect the immune response to fracture injury. Modern techniques used to investigate the relationship between immune system function and fracture healing include precision medicine, using vast quantities of data to interpret broad patterns of inflammatory response. Early data from the PRECISE trial have demonstrated distinct patterns of inflammatory response in polytrauma patients, which thereby directly and indirectly regulate the fracture healing response. The clearly demonstrated linkage between immune function and fracture healing suggests that modulation of immune function has significant potential as a therapeutic target that can be used to enhance fracture healing.

摘要

免疫系统在调节负责骨折愈合的细胞过程中发挥着不可或缺的作用。对骨折愈合的局部和全身影响在许多方面与骨折相关的结果相关，包括软组织愈合质量和骨折愈合率。软组织愈合受损、骨折部位灌注受限和感染反过来也会影响对骨折损伤的免疫反应。用于研究免疫系统功能与骨折愈合之间关系的现代技术包括精准医学，即利用大量数据来解读炎症反应的广泛模式。来自PRECISE试验的早期数据表明，多发伤患者存在不同的炎症反应模式，从而直接和间接地调节骨折愈合反应。免疫功能与骨折愈合之间明确的联系表明，调节免疫功能作为一种可用于促进骨折愈合的治疗靶点具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dead/10936162/a7438802f25e/oi9-7-e328-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dead/10936162/037cfacb665a/oi9-7-e328-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dead/10936162/5c10146e643d/oi9-7-e328-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dead/10936162/a7438802f25e/oi9-7-e328-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dead/10936162/037cfacb665a/oi9-7-e328-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dead/10936162/5c10146e643d/oi9-7-e328-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dead/10936162/a7438802f25e/oi9-7-e328-g003.jpg

相似文献

1
The local and systemic effects of immune function on fracture healing.免疫功能对骨折愈合的局部和全身影响。
OTA Int. 2024 Mar 11;7(2 Suppl):e328. doi: 10.1097/OI9.0000000000000328. eCollection 2024 Mar.
2
Osteoimmunology: Effects of Standard Orthopaedic Interventions on Inflammatory Response and Early Fracture Healing.骨免疫学：标准骨科干预对炎症反应和早期骨折愈合的影响。
J Am Acad Orthop Surg. 2018 May 15;26(10):343-352. doi: 10.5435/JAAOS-D-16-00646.
3
Burn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma.烧伤和胸部创伤会改变多发伤大鼠模型中的骨折愈合、全身炎症反应和白细胞动力学。
J Orthop Surg Res. 2019 Feb 19;14(1):58. doi: 10.1186/s13018-019-1082-4.
4
Neutralization of HMGB1 improves fracture healing and γδ T lymphocyte counts at the fracture site in a polytrauma rat model.在多创伤大鼠模型中，中和高迁移率族蛋白B1可改善骨折愈合及骨折部位的γδ T淋巴细胞计数。
J Exp Orthop. 2022 Feb 28;9(1):21. doi: 10.1186/s40634-022-00453-3.
5
MALADAPTIVE IMMUNE-FIBROTIC AXIS DRIVES IMPAIRED LONG BONE REGENERATION UNDER MECHANICAL INSTABILITY.适应性不良的免疫-纤维化轴驱动机械不稳定状态下长骨再生受损。
bioRxiv. 2025 May 13:2023.10.26.564177. doi: 10.1101/2023.10.26.564177.
6
Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.创伤性脑损伤导致的骨折反应差异表明，神经炎症反应在多发伤中占主导地位。
Sci Rep. 2019 Aug 21;9(1):12199. doi: 10.1038/s41598-019-48126-z.
7
Altered early immune response after fracture and traumatic brain injury.骨折和创伤性脑损伤后的早期免疫反应改变。
Front Immunol. 2023 Jan 25;14:1074207. doi: 10.3389/fimmu.2023.1074207. eCollection 2023.
8
Distinct defects in early innate and late adaptive immune responses typify impaired fracture healing in diet-induced obesity.饮食诱导肥胖症导致骨折愈合受损的特点是早期固有免疫和晚期适应性免疫反应存在明显缺陷。
Front Immunol. 2023 Oct 3;14:1250309. doi: 10.3389/fimmu.2023.1250309. eCollection 2023.
9
Enhancement of Impaired MRSA-Infected Fracture Healing by Combinatorial Antibiotics and Modulation of Sustained Inflammation.联合使用抗生素及调节持续性炎症对耐甲氧西林金黄色葡萄球菌感染所致骨折愈合受损的促进作用
J Bone Miner Res. 2022 Jul;37(7):1352-1365. doi: 10.1002/jbmr.4570. Epub 2022 Jun 19.
10
Intermittent pneumatic compression in fracture and soft-tissue injuries healing.间歇性气动压迫在骨折和软组织损伤愈合中的应用
Br Med Bull. 2008;88(1):147-56. doi: 10.1093/bmb/ldn024. Epub 2008 Jul 1.

引用本文的文献

1
Single-cell transcriptomic analysis identifies systemic immunosuppressive myeloid cells and local monocytes/macrophages as key regulators in polytrauma-induced immune dysregulation.单细胞转录组分析确定全身免疫抑制性髓系细胞和局部单核细胞/巨噬细胞是多创伤诱导的免疫失调的关键调节因子。
Bone Res. 2025 Jul 7;13(1):69. doi: 10.1038/s41413-025-00444-x.

本文引用的文献

1
Neutralization of HMGB1 improves fracture healing and γδ T lymphocyte counts at the fracture site in a polytrauma rat model.在多创伤大鼠模型中，中和高迁移率族蛋白B1可改善骨折愈合及骨折部位的γδ T淋巴细胞计数。
J Exp Orthop. 2022 Feb 28;9(1):21. doi: 10.1186/s40634-022-00453-3.
2
Modulating the systemic and local adaptive immune response after fracture improves bone regeneration during aging.调节骨折后全身和局部适应性免疫反应可改善衰老过程中的骨再生。
Bone. 2022 Apr;157:116324. doi: 10.1016/j.bone.2021.116324. Epub 2022 Jan 6.
3
Insights into the Cellular and Molecular Mechanisms That Govern the Fracture-Healing Process: A Narrative Review.
关于骨折愈合过程的细胞和分子机制的见解：一篇叙述性综述。
J Clin Med. 2021 Aug 12;10(16):3554. doi: 10.3390/jcm10163554.
4
Systemic T Cell Exhaustion Dynamics Is Linked to Early High Mobility Group Box Protein 1 (HMGB1) Driven Hyper-Inflammation in a Polytrauma Rat Model.全身性 T 细胞耗竭动力学与创伤性大鼠模型中早期高迁移率族蛋白 B1（HMGB1）驱动的过度炎症有关。
Cells. 2021 Jun 30;10(7):1646. doi: 10.3390/cells10071646.
5
Time Course of Immune Response and Immunomodulation During Normal and Delayed Healing of Musculoskeletal Wounds.骨骼肌创伤正常愈合和延迟愈合过程中的免疫应答和免疫调节的时程变化。
Front Immunol. 2020 Jun 4;11:1056. doi: 10.3389/fimmu.2020.01056. eCollection 2020.
6
The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells.调节性 T 细胞在固有免疫细胞调节中的关键作用。
Front Immunol. 2019 Apr 9;10:680. doi: 10.3389/fimmu.2019.00680. eCollection 2019.
7
The 'diamond concept' for long bone non-union management.“钻石概念”在长骨骨不连管理中的应用。
J Orthop Traumatol. 2019 Apr 11;20(1):21. doi: 10.1186/s10195-019-0528-0.
8
Burn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma.烧伤和胸部创伤会改变多发伤大鼠模型中的骨折愈合、全身炎症反应和白细胞动力学。
J Orthop Surg Res. 2019 Feb 19;14(1):58. doi: 10.1186/s13018-019-1082-4.
9
Topical rifampin powder for orthopaedic trauma part II: Topical rifampin allows for spontaneous bone healing in sterile and contaminated wounds.用于骨科创伤的局部用利福平粉末 第二部分：局部用利福平可促进无菌和污染伤口的自然骨愈合。
J Orthop Res. 2018 Dec;36(12):3142-3150. doi: 10.1002/jor.24155. Epub 2018 Oct 29.
10
Chronic biofilm-based infections: skewing of the immune response.慢性生物膜感染：免疫应答的偏倚。
Pathog Dis. 2018 Apr 1;76(3). doi: 10.1093/femspd/fty023.