Han Yiqun, Xue Tao, Kelly Frank J, Zheng Yixuan, Yao Yao, Li Jiajianghui, Li Jiwei, Fan Chun, Li Pengfei, Zhu Tong
Environmental Research Group, MRC Centre for Environment and Health, Imperial College London, London, UK.
BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Center for Environment and Health, Peking University, Beijing 100871, China.
Health Data Sci. 2022 Jan 15;2022:9846805. doi: 10.34133/2022/9846805. eCollection 2022.
. Increasing evidence from human studies has revealed the adverse impact of ambient fine particles (PM ) on health outcomes related to metabolic disorders and distant organs. Whether exposure to ambient PM leads to kidney impairment remains unclear. The rapid air quality improvement driven by the clean air actions in China since 2013 provides an opportunity for a quasiexperiment to investigate the beneficial effect of PM reduction on kidney function.. Based on two repeated nationwide surveys of the same population of 5115 adults in 2011 and 2015, we conducted a difference-in-difference study. Variations in long-term exposure to ambient PM were associated with changes in kidney function biomarkers, including estimated glomerular filtration rate by serum creatinine (GFR ) or cystatin C (GFR ), blood urea nitrogen (BUN), and uric acid (UA).. For a 10 g/m reduction in PM , a significant improvement was observed for multiple kidney functional biomarkers, including GFR , BUN and UA, with a change of 0.42 (95% confidence interval [CI]: 0.06, 0.78) mL/min/1.73m , -0.38 (-0.64, -0.12) mg/dL, and -0.06 (-0.12, -0.00) mg/dL, respectively. A lower socioeconomic status, indicated by rural residence or low educational level, enhanced the adverse effect of PM on kidney function.. These results support a significant nephrotoxicity of PM based on multiple serum biomarkers and indicate a beneficial effect of improved air quality on kidney function.
越来越多来自人体研究的证据揭示了环境细颗粒物（PM）对与代谢紊乱及远处器官相关的健康结局的不利影响。暴露于环境PM是否会导致肾脏损害仍不清楚。自2013年以来中国清洁空气行动推动的空气质量快速改善为一项准实验提供了机会，以研究PM减少对肾功能的有益影响。基于2011年和2015年对5115名成年人同一人群进行的两次全国性重复调查，我们开展了一项双重差分研究。长期暴露于环境PM的变化与肾功能生物标志物的变化相关，包括通过血清肌酐估算的肾小球滤过率（GFR）或胱抑素C估算的肾小球滤过率（GFR）、血尿素氮（BUN）和尿酸（UA）。对于PM每降低10μg/m³，观察到多种肾功能生物标志物有显著改善，包括GFR、BUN和UA，变化分别为0.42（95%置信区间[CI]：0.06，0.78）mL/min/1.73m²、-0.38（-0.64，-0.12）mg/dL和-0.06（-0.12，-0.00）mg/dL。农村居住或低教育水平所表明较低的社会经济地位增强了PM对肾功能的不利影响。这些结果基于多种血清生物标志物支持了PM具有显著肾毒性，并表明空气质量改善对肾功能有有益影响。
