Evaluation of novel synthesized thiazole derivatives as potential aromatase inhibitors against breast cancer.

4-Methylacetophenone is used in the preparation of starting materials, 4-methylphenacyle bromide () and 4-methylacetophenone thiosemicarbazole (). Several novel 2,4-disubstituted-1,3-thiazole analogues were obtained via the treatment of starting materials with 4-methylphenacyl bromide, acetyl chloride, aromatic aldehydes and bromination providing thiazole derivatives respectively. Compounds were investigated for their cytotoxic activity on MCF-7 and normal breast cells. Active compounds were found and in contrast to staurosporine, compound displayed the most potent cytotoxic action that showed a strong inhibitory effect (aromatase) and (protein tyrosine kinase) enzymes, proving that the novel thiazole derivatives promoted the effective anticancer drug candidates.