钯催化膦酰基联烯的区域选择性发散环化反应合成多芳基呋喃和2-色烯。
Pd-catalyzed divergent regioselective annulation of phosphinyl allenes accessing polyarylfurans and 2-chromenes.
作者信息
Li Yang, Yan Xiao-Long, Hu Li-Yan, Luo Kai, Zhu Jie, Wu Lei
机构信息
Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
School of Bioengineering, Huainan Normal University, Huainan, 232038, P. R. China.
出版信息
Chem Commun (Camb). 2024 Apr 2;60(28):3814-3817. doi: 10.1039/d3cc05974j.
A novel and efficient regioselective annulation of phosphinyl allenes with 2-bromophenol or 1-bromo-2-naphthol is achieved by palladium catalysis. The divergent pathway delivers structurally diverse polyarylfurans and 2-chromene skeletons two different Heck-type annulations. This protocol represents regioselectivity-tunable transformation of allenes into functionalized O-containing heterocycles with excellent group compatibility.
通过钯催化实现了膦酰基丙二烯与2-溴苯酚或1-溴-2-萘酚的新型高效区域选择性环化反应。不同的反应途径通过两种不同的Heck型环化反应生成结构多样的多芳基呋喃和2-色烯骨架。该方法代表了丙二烯向具有优异基团兼容性的官能化含氧杂环的区域选择性可调转化。
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