Department of Pediatric Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Emergency, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
J Child Neurol. 2024 Mar;39(3-4):113-121. doi: 10.1177/08830738241239703. Epub 2024 Mar 15.
The primary objective was to elucidate the epidemiologic characteristics, risk determinants, and clinical outcomes associated with -induced meningitis.
All cases of meningitis caused by that were treated at the hospital between 2012 and 2022 were retrospectively analyzed and detailed.
During a 10-year period, only 10 patients satisfied the inclusion criteria. Three patients had previously undergone neurosurgical procedures and 4 patients had leukemia.
Although meningitis possesses a low incidence rate, the rate of mortality is high. Patients with leukemia or those who have undergone neurosurgery are the most susceptible to diagnosis. Cases of severe neutropenia present only mild or no cerebrospinal fluid pleocytosis. In patients with sensitive meningitis, the timely use of anti- carbapenems for intravenous treatment is highly effective. For drug-resistant meningitis, intrathecal polymyxins administration can be an effective treatment option.
阐明与碳青霉烯类药物相关的脑膜炎的流行病学特征、风险决定因素和临床结局。
对 2012 年至 2022 年期间在我院接受治疗的所有由碳青霉烯类药物引起的脑膜炎病例进行回顾性分析和详细研究。
在 10 年期间，仅 10 名患者符合纳入标准。3 名患者曾接受过神经外科手术，4 名患者患有白血病。
虽然碳青霉烯类药物相关性脑膜炎的发病率较低，但死亡率较高。患有白血病或接受过神经外科手术的患者最易被诊断。严重中性粒细胞减少症患者的脑脊液白细胞仅轻度或无增多。对于敏感的碳青霉烯类药物相关性脑膜炎，及时使用抗碳青霉烯类药物静脉治疗非常有效。对于耐药的碳青霉烯类药物相关性脑膜炎，鞘内注射多黏菌素类药物是一种有效的治疗选择。
