Delhomme C, Adam T, Seiller H, Bursztejn A-C
Department of Dermatology, University Hospital of Nancy, France.
Department of Allergology, University Hospital of Nancy, France.
Ann Dermatol Venereol. 2024 Mar;151(1):103257. doi: 10.1016/j.annder.2024.103257. Epub 2024 Mar 15.
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Due to the burden of the disease, some patients try complementary and alternative medicine (CAM).
To identify characteristics associated with CAM use in children and adults with AD.
We conducted a literature review in accordance with the PRISMA international guidelines for literature reviews and meta-analyses. A systematic search was performed in the PubMed database. Qualitative and quantitative analyses using a χ test were performed to compare characteristics between CAM users and non-users. A p-value of <0.05 was considered statistically significant.
Out of 514 articles retrieved, 12 studies were included, giving a total of 2240 patients. Our statistical analysis identified an association between CAM use and rhino-conjunctivitis (p = 0.015 in children, p = 0.041 in adults), topical corticosteroid use (p = 0.042 in children, p = 0.008 in adults), and daily application of moisturizing cream (p = 0.002 in children, p < 0.001 in adults). Gender did not affect the decision to use CAM (p > 0.05). In studies, a higher number of affected eczema sites (p < 0.001), prior use of more than two conventional treatments (p = 0.047), and food avoidance diets (p = 0.016) were predictive of CAM use in children. In adults, a younger age (p < 0.05), higher education level (p = 0.043), and lower age at AD onset (p = 0.004) were related to CAM use.
To our knowledge, this is the first literature review focusing on socio-demographic and disease determinants related to CAM use among AD patients. The lack of homogeneity in measuring tools makes it difficult to compare and synthesize the studies.
特应性皮炎（AD）是一种慢性炎症性皮肤病。由于该病带来的负担，一些患者尝试使用补充和替代医学（CAM）。
确定AD儿童和成人使用CAM的相关特征。
我们按照PRISMA国际文献综述和荟萃分析指南进行了文献综述。在PubMed数据库中进行了系统检索。使用χ检验进行定性和定量分析，以比较CAM使用者和非使用者之间的特征。p值<0.05被认为具有统计学意义。
在检索到的514篇文章中，纳入了12项研究，共2240例患者。我们的统计分析确定了CAM使用与鼻结膜炎（儿童p = 0.015，成人p = 0.041）、外用糖皮质激素使用（儿童p = 0.042，成人p = 0.008）以及每日使用保湿霜（儿童p = 0.002，成人p < 0.001）之间存在关联。性别不影响使用CAM的决定（p > 0.05）。在研究中，儿童湿疹受累部位数量较多（p < 0.001）、先前使用过两种以上传统治疗方法（p = 0.047）以及食物回避饮食（p = 0.016）可预测CAM的使用。在成人中，年龄较小（p < 0.05）、教育水平较高（p = 0.043）以及AD发病年龄较低（p = 0.004）与CAM使用有关。
据我们所知，这是第一项关注AD患者中与CAM使用相关的社会人口统计学和疾病决定因素的文献综述。测量工具缺乏同质性使得难以对这些研究进行比较和综合。
