PET/CT Center, Department of Nuclear Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.
PET/CT Center, Department of Nuclear Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.
Clin Radiol. 2024 Jun;79(6):428-435. doi: 10.1016/j.crad.2024.01.020. Epub 2024 Feb 2.
To evaluate the diagnostic performance of 2-[F]-fluoro-2-deoxy-d-glucose (F-FDG) positron-emission tomography (PET)/computed tomography (CT) in TA diagnosis and Takayasu arteritis (TA) activity assessment.
This retrospective study included patients with TA diagnosed according to the American College of Rheumatology (ACR) criteria and undergoing F-FDG PET/CT imaging from October 2010 to July 2022. TA activity was assessed through F-FDG PET/CT (maximum standard uptake value [SUVmax], vascular SUVmax/mean standard uptake value [SUVmean] of liver (SUV ratio), and PET vascular activity score [PETVAS]) using physician global assessment (PGA) as the reference standard, and the results of these assessments were compared against the clinical activity scores (National Institutes of Health [NIH] and Indian Aortitis Disease Activity [ITAS-A] scores), acute-phase reactants (APR), and white blood cell and platelet counts.
Twenty F-FDG PET/CT examinations from 19 patients were included in the study, nine were performed in the active phase and 11 in the inactive phase. The involved vessels showed segmental and tubular FDG uptake in the active group. The average SUVmax, SUV ratio, and PETVAS was 6.3 ± 2.7 (range 3.4-12), 4.2 ± 1.7 (range 2.1-7.5), and 22.7 ± 11.2 (range 6-39), respectively, in the active group and 1.7 ± 0.9 (0.9-3.1), 1.1 ± 0.6 (range 0.6-2.4), and 3.5 ± 5.5 (range 0-18), respectively, in the inactive group. The sensitivity, specificity of SUVmax, SUV ratio, and PETVAS for TA activity assessment were 100%, 100%; 100%, 90.9%; and 88.9, 90.9%, respectively. After ROC curve analysis, a new SUVmax cut-off was obtained. Based on the new cut-off value, SUVmax 3.3 and SUV ratio 1.9 had a more perfect assessment performance.
F-FDG PET/CT is an alternative imaging technique for TA.
评估 2-[F]-氟-2-脱氧-d-葡萄糖（F-FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）在 Takayasu 动脉炎（TA）诊断和 TA 活动评估中的诊断性能。
本回顾性研究纳入了 2010 年 10 月至 2022 年 7 月期间根据美国风湿病学会（ACR）标准诊断为 TA 并接受 F-FDG PET/CT 成像的患者。TA 活动通过 F-FDG PET/CT（最大标准摄取值 [SUVmax]、血管 SUVmax/肝脏平均标准摄取值 [SUVmean] [SUV 比值] 和 PET 血管活动评分 [PETVAS]）进行评估，以医生总体评估（PGA）作为参考标准，并将这些评估结果与临床活动评分（美国国立卫生研究院 [NIH] 和印度大动脉炎疾病活动 [ITAS-A] 评分）、急性反应物（APR）以及白细胞和血小板计数进行比较。
研究纳入了 19 名患者的 20 次 F-FDG PET/CT 检查，其中 9 次在活动期进行，11 次在非活动期进行。在活动组中，受累血管显示出节段性和管状 FDG 摄取。在活动组中，SUVmax、SUV 比值和 PETVAS 的平均值分别为 6.3±2.7（范围 3.4-12）、4.2±1.7（范围 2.1-7.5）和 22.7±11.2（范围 6-39），而在非活动组中，SUVmax、SUV 比值和 PETVAS 的平均值分别为 1.7±0.9（0.9-3.1）、1.1±0.6（范围 0.6-2.4）和 3.5±5.5（范围 0-18）。SUVmax、SUV 比值和 PETVAS 用于评估 TA 活动的敏感性、特异性分别为 100%、100%；100%、90.9%；和 88.9%、90.9%。基于 ROC 曲线分析，得到了 SUVmax 的新截断值。基于新截断值，SUVmax 3.3 和 SUV 比值 1.9 具有更完美的评估性能。
F-FDG PET/CT 是 TA 的一种替代成像技术。
