优化神经抗体检测在副肿瘤性和自身免疫性脑炎临床实践中的诊断性能。
Optimizing the diagnostic performance of neural antibody testing for paraneoplastic and autoimmune encephalitis in clinical practice.
机构信息
Department of Clinical Neurological Sciences, Western University, London Health Sciences Centre, London, ON, Canada; Department of Pathology and Laboratory Medicine, Western University, London Health Sciences Centre, London, ON, Canada.
Department of Neurology, Mayo Clinic, Rochester, MN, United States; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
出版信息
Handb Clin Neurol. 2024;200:365-382. doi: 10.1016/B978-0-12-823912-4.00002-5.
The detection of neural antibodies in patients with paraneoplastic and autoimmune encephalitis has majorly advanced the diagnosis and management of neural antibody-associated diseases. Although testing for these antibodies has historically been restricted to specialized centers, assay commercialization has made this testing available to clinical chemistry laboratories worldwide. This improved test accessibility has led to reduced turnaround time and expedited diagnosis, which are beneficial to patient care. However, as the utilization of these assays has increased, so too has the need to evaluate how they perform in the clinical setting. In this chapter, we discuss assays for neural antibody detection that are in routine use, draw attention to their limitations and provide strategies to help clinicians and laboratorians overcome them, all with the aim of optimizing neural antibody testing for paraneoplastic and autoimmune encephalitis in clinical practice.
神经抗体在副肿瘤性和自身免疫性脑炎患者中的检测极大地推动了神经抗体相关疾病的诊断和治疗。尽管这些抗体的检测在历史上仅限于专门的中心进行，但检测方法的商业化已经使世界各地的临床化学实验室都能够进行这些检测。这种改进的测试可及性降低了周转时间并加快了诊断，这对患者护理有益。然而，随着这些检测的使用增加，评估它们在临床环境中的表现的需求也在增加。在本章中，我们讨论了常规使用的神经抗体检测方法，提请注意它们的局限性，并提供了帮助临床医生和实验室人员克服这些局限性的策略，所有这些都是为了优化神经抗体在临床实践中对副肿瘤性和自身免疫性脑炎的检测。
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