Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
Lipids Health Dis. 2024 Mar 17;23(1):80. doi: 10.1186/s12944-024-02065-5.
The study aimed to investigate the association between nonalcoholic fatty liver disease (NAFLD) and ischemic stroke events after revascularization in patients with Moyamoya disease (MMD).
This study prospectively enrolled 275 MMD patients from September 2020 to December 2021. Patients with alcoholism and other liver diseases were excluded. NAFLD was confirmed by CT imaging or abdominal ultrasonography. Stroke events and modified Rankin Scale (mRS) scores at the latest follow-up were compared between the two groups.
A total of 275 patients were enrolled in the study, among which 65 were diagnosed with NAFLD. Univariate logistic regression analysis showed that NAFLD (P = 0.029) was related to stroke events. Multivariate logistic regression analysis showed that NAFLD is a predictor of postoperative stroke in MMD patients (OR = 27.145, 95% CI = 2.031-362.81, P = 0.013). Kaplan-Meier analysis showed that compared with MMD patients with NAFLD, patients in the control group had a longer stroke-free time (P = 0.004). Univariate Cox analysis showed that NAFLD (P = 0.016) was associated with ischemic stroke during follow-up in patients with MMD. Multivariate Cox analysis showed that NAFLD was an independent risk factor for stroke in patients with MMD (HR = 10.815, 95% CI = 1.259-92.881, P = 0.030). Furthermore, fewer patients in the NAFLD group had good neurologic status (mRS score ≤ 2) than the control group (P = 0.005).
NAFLD was an independent risk factor for stroke in patients with MMD after revascularization and worse neurological function outcomes.
本研究旨在探讨非酒精性脂肪性肝病（NAFLD）与烟雾病（MMD）患者血管再通后缺血性卒中事件的关系。
本研究前瞻性纳入 2020 年 9 月至 2021 年 12 月期间的 275 例 MMD 患者。排除酒精性肝病和其他肝病患者。通过 CT 成像或腹部超声检查确认 NAFLD。比较两组患者的卒中事件和随访时的改良 Rankin 量表（mRS）评分。
本研究共纳入 275 例患者，其中 65 例诊断为 NAFLD。单因素 logistic 回归分析显示，NAFLD（P=0.029）与卒中事件相关。多因素 logistic 回归分析显示，NAFLD 是 MMD 患者术后卒中的预测因素（OR=27.145，95%CI=2.031-362.81，P=0.013）。Kaplan-Meier 分析显示，与 MMD 合并 NAFLD 患者相比，对照组患者的无卒中时间更长（P=0.004）。单因素 Cox 分析显示，NAFLD（P=0.016）与 MMD 患者随访期间的缺血性卒中相关。多因素 Cox 分析显示，NAFLD 是 MMD 患者卒中的独立危险因素（HR=10.815，95%CI=1.259-92.881，P=0.030）。此外，NAFLD 组的患者神经功能状态良好（mRS 评分≤2）的比例低于对照组（P=0.005）。
NAFLD 是 MMD 患者血管再通后卒中的独立危险因素，且神经功能预后较差。
