School of Life Science, Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical University, Bengbu, 233030, Anhui Province, China.
First Affiliated Hospital of Bengbu Medical University, Bengbu, 233030, Anhui Province, China.
Arch Microbiol. 2024 Mar 18;206(4):177. doi: 10.1007/s00203-024-03888-7.
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, has persisted as a major global public health threat for millennia. Until now, TB continues to challenge efforts aimed at controlling it, with drug resistance and latent infections being the two main factors hindering treatment efficacy. The scientific community is still striving to understand the underlying mechanisms behind Mtb's drug resistance and latent infection. DNA methylation, a critical epigenetic modification occurring throughout an individual's growth and development, has gained attention following advances in high-throughput sequencing technologies. Researchers have observed abnormal DNA methylation patterns in the host genome during Mtb infection. Given the escalating issue of drug-resistant Mtb, delving into the role of DNA methylation in TB's development is crucial. This review article explores DNA methylation's significance in human growth, development and disease, and its role in regulating Mtb's evolution and infection processes. Additionally, it discusses potential applications of DNA methylation research in tuberculosis.
结核病（TB）是一种由结核分枝杆菌（Mtb）感染引起的传染病，数千年来一直是全球主要的公共卫生威胁。直到现在，结核病仍然在挑战旨在控制它的努力，耐药性和潜伏感染是阻碍治疗效果的两个主要因素。科学界仍在努力了解 Mtb 耐药性和潜伏感染背后的潜在机制。DNA 甲基化是个体生长和发育过程中发生的一种关键的表观遗传修饰，随着高通量测序技术的进步，它受到了关注。研究人员在 Mtb 感染期间观察到宿主基因组中异常的 DNA 甲基化模式。鉴于耐药性 Mtb 问题的不断加剧，深入研究 DNA 甲基化在结核病发展中的作用至关重要。本文综述了 DNA 甲基化在人类生长、发育和疾病中的意义，以及它在调节 Mtb 的进化和感染过程中的作用。此外，还讨论了 DNA 甲基化研究在结核病中的潜在应用。
