Liu Nan, Dong Jinlei, Li Lianxin, Zhou Dongsheng, Liu Fanxiao
Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People's Republic of China.
J Inflamm Res. 2024 Mar 11;17:1607-1619. doi: 10.2147/JIR.S455790. eCollection 2024.
Metrnl, recently identified as an adipokine, is a secreted protein notably expressed in white adipose tissue, barrier tissues, and activated macrophages. This adipokine plays a pivotal role in counteracting obesity-induced insulin resistance. It enhances adipose tissue functionality by promoting adipocyte differentiation, activating metabolic pathways, and exerting anti-inflammatory effects. Extensive research has identified Metrnl as a key player in modulating inflammatory responses and as an integral regulator of muscle regeneration. These findings position Metrnl as a promising biomarker and potential therapeutic target in treating inflammation-associated pathologies. Despite this, the specific anti-inflammatory mechanisms of Metrnl in immune-mediated osteolysis and arthritis remain elusive, warranting further investigation. In this review, we will briefly elaborate on the role of Metrnl in anti-inflammation function in inflammation-related osteolysis, arthritis, and pathological bone resorption, which could facilitate Metrnl's clinical application as a novel therapeutic strategy to prevent bone loss. While the pathogenesis of elbow stiffness remains elusive, current literature suggests that Metrnl likely exerts a pivotal role in its development.
Metrnl是一种最近被鉴定为脂肪因子的分泌蛋白，在白色脂肪组织、屏障组织和活化巨噬细胞中显著表达。这种脂肪因子在对抗肥胖诱导的胰岛素抵抗中起关键作用。它通过促进脂肪细胞分化、激活代谢途径和发挥抗炎作用来增强脂肪组织功能。广泛的研究已确定Metrnl是调节炎症反应的关键因子和肌肉再生的重要调节因子。这些发现使Metrnl成为治疗炎症相关疾病的有前景的生物标志物和潜在治疗靶点。尽管如此，Metrnl在免疫介导的骨溶解和关节炎中的具体抗炎机制仍不清楚，需要进一步研究。在这篇综述中，我们将简要阐述Metrnl在炎症相关骨溶解、关节炎和病理性骨吸收的抗炎功能中的作用，这可能有助于将Metrnl作为预防骨质流失的新型治疗策略应用于临床。虽然肘关节僵硬的发病机制尚不清楚，但目前的文献表明Metrnl可能在其发展中起关键作用。
