Hiruta M
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Jul;37(7):1156-60.
In this study, urinary kallikrein quantity and activity were measured by the kallikrein direct RIA and kininogenase activity with human low molecular weight kininogen in 32 non pregnant healthy women and 20 normal 3rd trimester pregnant women. There was no significant difference in urinary kallikrein quantity between non pregnant healthy women (n=32, 64.0 +/- 6.3 micrograms/day, mean +/- S.E.) and normal pregnant women (n=20, 68.1 +/- 10.1 micrograms/day). There was a significant difference (p less than 0.05) in urinary kallikrein activity between non pregnant healthy women (n=32, 496.2 +/- 57.2 micrograms kinin/day) and normal pregnant women (n=20, 319.5 +/- 48.1 micrograms kinin/day). The reason for no significant difference in the urinary kallikrein quantity may be that neither non pregnant women nor normal pregnant women have renal damage. And, one of the reasons for significant low urinary kallikrein activity in normal pregnant women may be that the sensitivity of blood vessels to angiotensin II in normal pregnancy is less than in non pregnancy.
在本研究中，采用激肽释放酶直接放射免疫分析法测定了32名未孕健康女性和20名孕晚期正常孕妇尿激肽释放酶的含量及活性，并用人低分子量激肽原测定了激肽原酶活性。未孕健康女性（n = 32，64.0±6.3微克/天，均值±标准误）与正常孕妇（n = 20，68.1±10.1微克/天）的尿激肽释放酶含量无显著差异。未孕健康女性（n = 32，496.2±57.2微克激肽/天）与正常孕妇（n = 20，319.5±48.1微克激肽/天）的尿激肽释放酶活性存在显著差异（p＜0.05）。尿激肽释放酶含量无显著差异的原因可能是未孕女性和正常孕妇均无肾损害。而且，正常孕妇尿激肽释放酶活性显著降低的原因之一可能是正常妊娠时血管对血管紧张素II的敏感性低于非妊娠状态。
