在颈动脉内膜切除术中测量搏动性皮质血流和血容量。
Measuring pulsatile cortical blood flow and volume during carotid endarterectomy.
作者信息
Zavriyev Alexander I, Kaya Kutlu, Wu Kuan Cheng, Pierce Eric T, Franceschini Maria Angela, Robinson Mitchell B
机构信息
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Biomed Opt Express. 2024 Feb 2;15(3):1355-1369. doi: 10.1364/BOE.507730. eCollection 2024 Mar 1.
Carotid endarterectomy (CEA) involves removal of plaque in the carotid artery to reduce the risk of stroke and improve cerebral perfusion. This study aimed to investigate the utility of assessing pulsatile blood volume and flow during CEA. Using a combined near-infrared spectroscopy/diffuse correlation spectroscopy instrument, pulsatile hemodynamics were assessed in 12 patients undergoing CEA. Alterations to pulsatile amplitude, pulse transit time, and beat morphology were observed in measurements ipsilateral to the surgical side. The additional information provided through analysis of pulsatile hemodynamic signals has the potential to enable the discovery of non-invasive biomarkers related to cortical perfusion.
颈动脉内膜切除术（CEA）包括清除颈动脉中的斑块，以降低中风风险并改善脑灌注。本研究旨在探讨在CEA期间评估搏动血容量和血流的效用。使用近红外光谱/扩散相关光谱联用仪器，对12例接受CEA的患者进行了搏动血流动力学评估。在手术侧同侧的测量中观察到搏动幅度、脉搏传输时间和搏动形态的改变。通过分析搏动血流动力学信号提供的额外信息有可能发现与皮质灌注相关的非侵入性生物标志物。
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