Boonpucknavig V, Boonpucknavig S, Bhamarapravati N
Arch Pathol Lab Med. 1979 Oct;103(11):567-72.
Twenty-one male Swiss albino mice were injected intraperitoneally with 2 x 10(5) Plasmodium berghei berghei-infected cells. Twenty-four mice were used as a noninfected control group. On the tenth day after infection, three mice were killed and the remainder were treated with chloroquine phosphate (0.025% solution) given orally. The dosage was subsequently adjusted to keep the parasitemia below 5%. Eighteen of the controls received the same chloroquine dosage. Diffuse proliferative glomerulonephritis was seen from day 10 of infection up to two months after treatment. Granular deposits of immune complex were seen in all glomeruli. At the end of third month and thereafter, all experimental mice were in a hyperimmune state, and the kidneys showed the characteristic of focal glomerulonephritis resembling some types of human focal glomerulonephritis.
将2×10⁵感染伯氏疟原虫的细胞腹腔注射给21只雄性瑞士白化小鼠。24只小鼠作为未感染的对照组。感染后第10天，处死3只小鼠，其余小鼠口服磷酸氯喹（0.025%溶液）进行治疗。随后调整剂量以使寄生虫血症低于5%。18只对照组小鼠接受相同的氯喹剂量。从感染第10天到治疗后两个月均可见弥漫性增殖性肾小球肾炎。在所有肾小球中均可见免疫复合物的颗粒状沉积。在第三个月末及之后，所有实验小鼠均处于超免疫状态，肾脏表现出类似于某些类型人类局灶性肾小球肾炎的局灶性肾小球肾炎特征。
