University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Saint Louis University Transplant Center, SSM Health Saint Louis University Hospital, St. Louis, Missouri, USA.
Am J Transplant. 2024 Aug;24(8):1473-1485. doi: 10.1016/j.ajt.2024.03.010. Epub 2024 Mar 16.
In the United States, potential transplant candidates with insulin-dependent diabetes mellitus are inconsistently offered pancreas transplantation (PTx), contributing to a dramatic decline in pancreas allograft utilization over the past 2 decades. The American Society of Transplantation organized a workshop to identify barriers inhibiting PTx and to develop strategies for a national comeback. The 2-day workshop focused on 4 main topics: (1) referral/candidate selection, (2) organ recovery/utilization, (3) program performance/patient outcomes, and (4) enhanced education/research. Topics were explored through expert presentations, patient testimonials, breakout sessions, and strategic planning, including the identification of tasks for immediate focus. Additionally, a modified-Delphi survey was conducted among workshop members to develop and rate the importance of barriers, and the impact and feasibility of workgroup-identified improvement strategies. The panelists identified 16 barriers to progress and 44 strategies for consideration. The steps for a national comeback in PTx involve greater emphasis on efficient referral and candidate selection, better donor pancreas utilization practices, eliminating financial barriers to procurement and transplant, improving collaboration between transplant and diabetes societies and professionals, and increasing focus on PTx training, education, and research. Partnership between national societies, patient advocacy groups, and professionals will be essential to realizing this critical agenda.
在美国,患有胰岛素依赖型糖尿病的潜在移植候选者接受胰腺移植 (PTx) 的情况不一致,这导致过去 20 年来胰腺移植物的利用率大幅下降。美国移植学会组织了一次研讨会,以确定阻碍 PTx 的障碍,并制定全国复苏的策略。为期两天的研讨会集中讨论了 4 个主要主题:(1) 转诊/候选者选择,(2) 器官回收/利用,(3) 项目绩效/患者结果,和 (4) 强化教育/研究。通过专家演讲、患者证言、分组讨论和战略规划探讨了这些主题,包括确定当前关注的任务。此外,还对研讨会成员进行了改良 Delphi 调查,以制定和评估障碍的重要性,以及工作组确定的改进策略的影响和可行性。专题小组成员确定了 16 个进展障碍和 44 个可供考虑的策略。PTx 全国复苏的步骤包括更加重视有效的转诊和候选者选择,改进供体胰腺的利用实践,消除获取和移植的财务障碍,改善移植和糖尿病协会及专业人员之间的合作,以及更加关注 PTx 的培训、教育和研究。国家协会、患者权益团体和专业人员之间的合作将是实现这一重要议程的关键。