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二甲双胍和进食增加了人类中抑制食欲的代谢物 Lac-Phe 的水平。

Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.

机构信息

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

出版信息

Nat Metab. 2024 Apr;6(4):651-658. doi: 10.1038/s42255-024-01018-7. Epub 2024 Mar 18.

DOI:10.1038/s42255-024-01018-7
PMID:38499765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11052712/
Abstract

Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N-lactoyl phenylalanine (Lac-Phe) in the blood of individuals treated with metformin across seven observational and interventional studies. Furthermore, Lac-Phe levels were found to rise in response to acute metformin administration and post-prandially in patients with T2D or in metabolically healthy volunteers.

摘要

二甲双胍是一种广泛用于 2 型糖尿病（T2D）的一线治疗药物，已知可降低血糖水平并抑制食欲。在这里，我们报告了在接受二甲双胍治疗的个体的血液中，一种抑制食欲的代谢物 N-乳酰苯丙氨酸（Lac-Phe）显著升高，这涉及到七个观察性和干预性研究。此外，发现 Lac-Phe 水平在 T2D 患者或代谢健康的志愿者中，急性给予二甲双胍和餐后会升高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beba/11052712/1c06e88e8cea/42255_2024_1018_Fig5_ESM.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beba/11052712/46d88465d863/42255_2024_1018_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beba/11052712/771df75272ce/42255_2024_1018_Fig2_HTML.jpg
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