环磷酰胺对高转移性MAT 13762肿瘤的化学免疫治疗效果。

Chemoimmunotherapeutic effect of cyclophosphamide on the highly metastatic MAT 13762 tumor.

作者信息

Hoon D S, Ramshaw I A

出版信息

Cancer Immunol Immunother. 1985;20(2):175-8. doi: 10.1007/BF00205685.

DOI:10.1007/BF00205685

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038916/

Abstract

We have observed that cyclophosphamide (CY) treatment of 13762 mammary adenocarcinoma tumor-bearing rats was found to cause tumor regression. Tumor-bearing animals cured with three low doses of CY were partially immune against IV and SC challenge with a high dose of 13762 cells. This immune protection mechanism in CY-cured animals appears to be a T (Ig-) cell-mediated response. Irradiated rats reconstituted with CY-cured animal spleen cells were also partially protected against IV and SC challenge with 13762 cells, whereas irradiated rats reconstituted with CY-control animal spleen cells were not. In vitro primary and secondary cell-mediated cytotoxic activity of CY-cured spleen cells against target 13762 cells was low. The possible relevance of this tumor-model study is in the understanding of CY-induced tumor immune response and its role in preventing metastases or perhaps recurrent tumor growth.

摘要

我们观察到，用环磷酰胺（CY）治疗携带13762乳腺腺癌的大鼠会导致肿瘤消退。用三个低剂量CY治愈的荷瘤动物对高剂量13762细胞的静脉注射和皮下攻击具有部分免疫力。CY治愈动物中的这种免疫保护机制似乎是一种T（Ig-）细胞介导的反应。用CY治愈动物的脾细胞重建的辐照大鼠也对13762细胞的静脉注射和皮下攻击具有部分保护作用，而用CY对照动物的脾细胞重建的辐照大鼠则没有。CY治愈的脾细胞对靶13762细胞的体外初次和二次细胞介导的细胞毒性活性较低。这项肿瘤模型研究的可能意义在于了解CY诱导的肿瘤免疫反应及其在预防转移或可能的复发性肿瘤生长中的作用。

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引用本文的文献

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本文引用的文献

1

Cyclophosphamide and urinary bladder toxicity.环磷酰胺与膀胱毒性。

Cancer Res. 1961 Dec;21:1577-89.

2

Cooperation between cyclophosphamide tumoricidal activity and host antitumor immunity in the cure of mice bearing large MOPC-315 tumors.环磷酰胺的杀肿瘤活性与宿主抗肿瘤免疫在治愈携带大的MOPC - 315肿瘤小鼠中的协同作用。

Cancer Res. 1981 Jun;41(6):2163-7.

3

Interference of anti-tumor and immunosuppressive effects of cyclophosphamide in tumor-bearing rats. Analysis of factors determining resistance or susceptibility to a subsequent tumor challenge.环磷酰胺对荷瘤大鼠抗肿瘤及免疫抑制作用的干扰。对决定对后续肿瘤攻击产生抗性或易感性的因素的分析。

Cancer Immunol Immunother. 1982;14(1):36-40. doi: 10.1007/BF00199430.

4

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J Immunol. 1980 Aug;125(2):738-48.

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Int J Cancer. 1982 Nov 15;30(5):601-7. doi: 10.1002/ijc.2910300511.

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Cancer Res. 1984 Nov;44(11):5439-43.

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