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环磷酰胺对高转移性MAT 13762肿瘤的化学免疫治疗效果。

Chemoimmunotherapeutic effect of cyclophosphamide on the highly metastatic MAT 13762 tumor.

作者信息

Hoon D S, Ramshaw I A

出版信息

Cancer Immunol Immunother. 1985;20(2):175-8. doi: 10.1007/BF00205685.

DOI:10.1007/BF00205685
PMID:3849980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038916/
Abstract

We have observed that cyclophosphamide (CY) treatment of 13762 mammary adenocarcinoma tumor-bearing rats was found to cause tumor regression. Tumor-bearing animals cured with three low doses of CY were partially immune against IV and SC challenge with a high dose of 13762 cells. This immune protection mechanism in CY-cured animals appears to be a T (Ig-) cell-mediated response. Irradiated rats reconstituted with CY-cured animal spleen cells were also partially protected against IV and SC challenge with 13762 cells, whereas irradiated rats reconstituted with CY-control animal spleen cells were not. In vitro primary and secondary cell-mediated cytotoxic activity of CY-cured spleen cells against target 13762 cells was low. The possible relevance of this tumor-model study is in the understanding of CY-induced tumor immune response and its role in preventing metastases or perhaps recurrent tumor growth.

摘要

我们观察到，用环磷酰胺（CY）治疗携带13762乳腺腺癌的大鼠会导致肿瘤消退。用三个低剂量CY治愈的荷瘤动物对高剂量13762细胞的静脉注射和皮下攻击具有部分免疫力。CY治愈动物中的这种免疫保护机制似乎是一种T（Ig-）细胞介导的反应。用CY治愈动物的脾细胞重建的辐照大鼠也对13762细胞的静脉注射和皮下攻击具有部分保护作用，而用CY对照动物的脾细胞重建的辐照大鼠则没有。CY治愈的脾细胞对靶13762细胞的体外初次和二次细胞介导的细胞毒性活性较低。这项肿瘤模型研究的可能意义在于了解CY诱导的肿瘤免疫反应及其在预防转移或可能的复发性肿瘤生长中的作用。

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引用本文的文献

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A 6-thioguanine-resistant variant of the rat mammary adenocarcinoma 13762 that is more immunogenic.大鼠乳腺腺癌13762的一种对6-硫鸟嘌呤耐药的变体，其免疫原性更强。
Cancer Immunol Immunother. 1987;24(1):42-8. doi: 10.1007/BF00199831.
2
Augmentation of host antitumor immunity by low doses of cyclophosphamide and mafosfamide in two animal tumor models.低剂量环磷酰胺和马磷酰胺在两种动物肿瘤模型中增强宿主抗肿瘤免疫力
Cancer Immunol Immunother. 1989;28(3):179-84. doi: 10.1007/BF00204986.

本文引用的文献

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Cyclophosphamide and urinary bladder toxicity.环磷酰胺与膀胱毒性。
Cancer Res. 1961 Dec;21:1577-89.
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Cooperation between cyclophosphamide tumoricidal activity and host antitumor immunity in the cure of mice bearing large MOPC-315 tumors.环磷酰胺的杀肿瘤活性与宿主抗肿瘤免疫在治愈携带大的MOPC - 315肿瘤小鼠中的协同作用。
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Interference of anti-tumor and immunosuppressive effects of cyclophosphamide in tumor-bearing rats. Analysis of factors determining resistance or susceptibility to a subsequent tumor challenge.环磷酰胺对荷瘤大鼠抗肿瘤及免疫抑制作用的干扰。对决定对后续肿瘤攻击产生抗性或易感性的因素的分析。
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The relationship between tumor antigens and alloantigens: cross-reactivity due to differential context of T cell antigen recognition.肿瘤抗原与同种异体抗原之间的关系：由于T细胞抗原识别的不同背景导致的交叉反应性。
J Immunol. 1980 Aug;125(2):738-48.
5
A 6-thioguanine-resistant variant of the 13762 cell line which is no longer tumorigenic or metastatic.13762细胞系的一种对6-硫鸟嘌呤耐药的变体，该变体不再具有致瘤性或转移性。
Int J Cancer. 1982 Nov 15;30(5):601-7. doi: 10.1002/ijc.2910300511.
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Circulating immune complexes and immunoglobulin M-class rheumatoid factor in rats bearing mammary adenocarcinomas which vary in ability to metastasize.患有转移能力各异的乳腺腺癌的大鼠体内的循环免疫复合物和免疫球蛋白M类类风湿因子
Cancer Res. 1983 Jan;43(1):114-9.
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Phenotypes associated with tumor rejection mediated by cyclophosphamide and syngeneic tumor-sensitized T lymphocytes: potential mechanisms of action.与环磷酰胺和同基因肿瘤致敏T淋巴细胞介导的肿瘤排斥相关的表型：潜在作用机制
Int J Cancer. 1984 Mar 15;33(3):381-8. doi: 10.1002/ijc.2910330317.
8
Potentiation of human cell-mediated and humoral immunity by low-dose cyclophosphamide.低剂量环磷酰胺增强人体细胞介导免疫和体液免疫
Cancer Res. 1984 Nov;44(11):5439-43.
9
Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.环磷酰胺辅助的已建立肿瘤的过继性免疫疗法取决于肿瘤诱导的抑制性T细胞的清除。
J Exp Med. 1982 Apr 1;155(4):1063-74. doi: 10.1084/jem.155.4.1063.
10
Effect of cyclophosphamide on immunological control mechanisms.环磷酰胺对免疫控制机制的影响。
Immunol Rev. 1982;65:99-113. doi: 10.1111/j.1600-065x.1982.tb00429.x.

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