Groth C G, Gahrton G, Lundgren G, Möller E, Pihlstedt P, Ringdén O, Sundelin P
Scand J Haematol. 1979 Apr 4;22(4):333-8. doi: 10.1111/j.1600-0609.1979.tb00428.x.
A 51-year-old patient with aplastic anaemia in whom a successful allogeneic bone-marrow transplantation had been performed developed acute graft-versus-host disease in spite of prophylactic administration of methotrexate. There was severe liver injury but no involvement of the skin or intestines. When prednisone therapy was introduced the fever and the eosinophilia disappeared and liver damage was rapidly reversed. There was no haematological impairment. It would seem warranted to consider a wider use of prednisone in the treatment of acute GVHD in human recipients of allogeneic bone-marrow.
一名51岁的再生障碍性贫血患者，尽管预防性使用了甲氨蝶呤，但在进行了成功的异基因骨髓移植后仍发生了急性移植物抗宿主病。患者有严重的肝损伤，但皮肤和肠道未受累。引入泼尼松治疗后，发热和嗜酸性粒细胞增多消失，肝损伤迅速逆转。血液学未受损害。似乎有必要考虑在异基因骨髓人类受者的急性移植物抗宿主病治疗中更广泛地使用泼尼松。
