Department of Rehabilitation, Hangzhou First People's Hospital, 310000, Hangzhou, China.
Department of Radiology, Hangzhou First People's Hospital, 310000, Hangzhou, China.
BMC Med Imaging. 2024 Mar 18;24(1):66. doi: 10.1186/s12880-024-01239-y.
To investigate the altered trends of regional homogeneity (ReHo) based on time and frequency, and clarify the time-frequency characteristics of ReHo in 48 classical trigeminal neuralgia (CTN) patients after a single pain stimulate.
All patients underwent three times resting-state functional MRI (before stimulation (baseline), after stimulation within 5 s (triggering-5 s), and in the 30th min of stimulation (triggering-30 min)). The spontaneous brain activity was investigated by static ReHo (sReHo) in five different frequency bands and dynamic ReHo (dReHo) methods.
In the five frequency bands, the number of brain regions which the sReHo value changed in classical frequency band were most, followed by slow 4 frequency band. The left superior occipital gyrus was only found in slow 2 frequency band and the left superior parietal gyrus was only found in slow 3 frequency band. The dReHo values were changed in midbrain, left thalamus, right putamen, and anterior cingulate cortex, which were all different from the brain regions that the sReHo value altered. There were four altered trends of the sReHo and dReHo, which dominated by decreased at triggering-5 s and increased at triggering-30 min.
The duration of brain function changed was more than 30 min after a single pain stimulate, although the pain of CTN was transient. The localized functional homogeneity has time-frequency characteristic in CTN patients after a single pain stimulate, and the changed brain regions of the sReHo in five frequency bands and dReHo complemented to each other. Which provided a certain theoretical basis for exploring the pathophysiology of CTN.
基于时间和频率探索局部一致性（ReHo）的改变趋势，并阐明 48 例原发性三叉神经痛（CTN）患者单次疼痛刺激后 ReHo 的时频特征。
所有患者均接受 3 次静息态功能磁共振成像（刺激前（基线）、刺激后 5s（触发-5s）和刺激后 30min（触发-30min））。采用静态 ReHo（sReHo）和动态 ReHo（dReHo）方法研究自发性脑活动。
在五个不同的频率带中，sReHo 值发生变化的脑区数量最多，其次是慢 4 频带。左枕上回仅见于慢 2 频带，左顶上回仅见于慢 3 频带。dReHo 值发生变化的脑区位于中脑、左侧丘脑、右侧壳核和前扣带回，均与 sReHo 值改变的脑区不同。sReHo 和 dReHo 有四种改变趋势，以触发-5s 时减少和触发-30min 时增加为主。
尽管 CTN 的疼痛是短暂的，但单次疼痛刺激后大脑功能的改变持续时间超过 30min。原发性三叉神经痛患者单次疼痛刺激后局部功能同质性具有时频特征，sReHo 五个频带和 dReHo 的改变脑区相互补充。为探讨 CTN 的病理生理学提供了一定的理论依据。
