Sack K, Marre R, Freiesleben H, Henkel W
Arzneimittelforschung. 1979;29(2a):414-6.
The therapeutic effectiveness of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen), cephazolin, cephacetrile and cephalothin was compared in the test model of estradiol-induced E. coli pyelonephritis in the rat. Cefazedone and cephazolin were similar in effect. The relations between results of treatment and microbiological and pharmacokinetic characteristics of the cephalosporins tested are discussed.
在大鼠雌二醇诱导的大肠杆菌肾盂肾炎试验模型中，比较了（6R，7R）-7-（2-[3,5-二氯-4-氧代-1（4H）-吡啶基]-乙酰氨基）-3-（[(5-甲基-1,3,4-噻二唑-2-基）-硫代]甲基）-8-氧代-5-硫杂-1-氮杂双环[4,2,0]辛-2-烯-2-羧酸（头孢地嗪，瑞呋孢菌素）、头孢唑林、头孢乙腈和头孢噻吩的治疗效果。头孢地嗪和头孢唑林效果相似。讨论了所测试头孢菌素的治疗结果与微生物学及药代动力学特征之间的关系。
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