Li Ming-Jun, Lu Ming-Ming, Xu Peng, Chen Si-Qi, Wu Luan-Ting, Zhang Ze, Xu Hui
School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, P. R. China.
Chem Commun (Camb). 2024 Apr 4;60(29):3958-3961. doi: 10.1039/d3cc06327e.
A novel and interesting controllable spirocyclization of unsaturated barbiturates with enamino esters for the assembly of cyclopentenyl and pyrrolinyl spirobarbiturates has been developed under ball-milling conditions. The present protocol features high chemoselectivity and efficiency, excellent functional group tolerance and mild reaction conditions.
在球磨条件下，已开发出一种新颖且有趣的不饱和巴比妥酸盐与烯胺酯的可控螺环化反应，用于合成环戊烯基和吡咯啉基螺环巴比妥酸盐。本方法具有高化学选择性和效率、出色的官能团耐受性以及温和的反应条件。
