由不饱和巴比妥酸盐和烯胺酯进行环戊烯基和吡咯啉基螺环巴比妥酸盐的化学发散性机械合成。
Chemodivergent mechanosynthesis of cyclopentenyl and pyrrolinyl spirobarbiturates from unsaturated barbiturates and enamino esters.
作者信息
Li Ming-Jun, Lu Ming-Ming, Xu Peng, Chen Si-Qi, Wu Luan-Ting, Zhang Ze, Xu Hui
机构信息
School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, P. R. China.
出版信息
Chem Commun (Camb). 2024 Apr 4;60(29):3958-3961. doi: 10.1039/d3cc06327e.
PMID:38501223
Abstract
A novel and interesting controllable spirocyclization of unsaturated barbiturates with enamino esters for the assembly of cyclopentenyl and pyrrolinyl spirobarbiturates has been developed under ball-milling conditions. The present protocol features high chemoselectivity and efficiency, excellent functional group tolerance and mild reaction conditions.
摘要
在球磨条件下，已开发出一种新颖且有趣的不饱和巴比妥酸盐与烯胺酯的可控螺环化反应，用于合成环戊烯基和吡咯啉基螺环巴比妥酸盐。本方法具有高化学选择性和效率、出色的官能团耐受性以及温和的反应条件。
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