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左旋咪唑治疗复发性尿路感染

[Levamisol in the treatment of recurrent urinary tract infections].

作者信息

Lubetkin A M, Remedi R F, Granero M, Brarda O

出版信息

Bol Med Hosp Infant Mex. 1979 Nov-Dec;36(6):1109-12.

PMID:385017
Abstract

Levamisole, a widely used antihelminthic drug, possesses immunotropic properties. It has been proved that children with recurrent infections of the respiratory tract who were given the drug, were capable of preventing the repetition of the infections. Twenty-seven (27) children with recurrent urinary tract infections without structural malformations were studied and in all of them, a diminished cellular immunity was detected (blastic transformation of lymphocytes, rosettes of T lymphocytes and the skin tests). The drug was administered in doses of 2.5 mg/k/day, twice a week, for eight months. During the period of study, in 21 children repetition of the infections were not detected and in 13, a significant improvement of the cellular immunity was achieved. In some children it was possible to prove a rise of the IgA secretary in the urine.

摘要

左旋咪唑是一种广泛使用的抗蠕虫药,具有免疫调节特性。已证实,服用该药物的反复呼吸道感染儿童能够预防感染复发。对27名无结构畸形的反复尿路感染儿童进行了研究,发现他们均存在细胞免疫功能降低(淋巴细胞的母细胞转化、T淋巴细胞玫瑰花结形成及皮肤试验)。以2.5毫克/千克/天的剂量给药,每周两次,持续八个月。在研究期间,21名儿童未检测到感染复发,13名儿童的细胞免疫功能有显著改善。在一些儿童中,还证实尿液中分泌型IgA升高。

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