Ma Ke, Chen Ke-Zheng, Qiao Sheng-Lin
Lab of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology (QUST), Qingdao, 266042, P. R. China.
Chem Rec. 2024 Apr;24(4):e202400010. doi: 10.1002/tcr.202400010. Epub 2024 Mar 19.
Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist of orthorhombic arrays of metal hydroxides with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced drug bioavailability, LDHs have many potential applications in the medical field. Especially in the fields of bioimaging and tumor therapy. This paper reviews the research progress of LDHs and their nanocomposites in the field of tumor imaging and therapy. First, the structure and advantages of LDH are discussed. Then, several commonly used methods for the preparation of LDH are presented, including co-precipitation, hydrothermal and ion exchange methods. Subsequently, recent advances in layered hydroxides and their nanocomposites for cancer imaging and therapy are highlighted. Finally, based on current research, we summaries the prospects and challenges of layered hydroxides and nanocomposites for cancer diagnosis and therapy.
层状双氢氧化物（LDH）是一类功能性阴离子粘土，通常由金属氢氧化物的正交阵列组成，阴离子夹在层间。由于其独特的性质，包括高化学稳定性、良好的生物相容性、可控的药物负载和提高的药物生物利用度，LDH在医学领域有许多潜在应用。特别是在生物成像和肿瘤治疗领域。本文综述了LDH及其纳米复合材料在肿瘤成像和治疗领域的研究进展。首先，讨论了LDH的结构和优点。然后，介绍了几种常用的LDH制备方法，包括共沉淀法、水热法和离子交换法。随后，重点介绍了层状氢氧化物及其纳米复合材料在癌症成像和治疗方面的最新进展。最后，基于当前的研究，我们总结了层状氢氧化物和纳米复合材料在癌症诊断和治疗方面的前景和挑战。
