Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
J Mater Chem B. 2019 Sep 25;7(37):5583-5601. doi: 10.1039/c9tb01312a.
Layered double hydroxide (LDH) nanostructures and related nanocomposites have attracted significant interest in biomedical applications including cancer therapy, bioimaging and antibacterial treatment. These materials hold great advantages including low cost and facile preparation, convenient drug loading, high drug incorporation capacity, good biocompatibility, efficient intracellular uptake and endosome/lysosome escape, and natural biodegradability in an acidic environment. In this review, we summarize the development of three types of LDH nanostructures including pristine LDH, surface modified LDH, and LDH nanocomposites for a range of biomedical applications. The advantages and disadvantages of LDH nanostructures and insights into the future development are also discussed.
层状双氢氧化物（LDH）纳米结构及其相关纳米复合材料在包括癌症治疗、生物成像和抗菌处理在内的生物医学应用中引起了极大的关注。这些材料具有低成本、易于制备、方便药物负载、高载药能力、良好的生物相容性、高效的细胞内摄取和内涵体/溶酶体逃逸以及在酸性环境中的天然可生物降解性等优点。在这篇综述中，我们总结了三种类型的 LDH 纳米结构的发展，包括原始 LDH、表面改性 LDH 和 LDH 纳米复合材料，用于一系列生物医学应用。还讨论了 LDH 纳米结构的优缺点以及对未来发展的见解。
