基因融合促进有序和温敏性结构单元设计杂化生物材料。
Genetically Fusing Order-Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials.
机构信息
Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, 19716, United States.
Eli Lilly and Company, 450 Kendall Street, Cambridge, MA, 02142, United States.
出版信息
Chemistry. 2024 May 28;30(30):e202400582. doi: 10.1002/chem.202400582. Epub 2024 Apr 10.
The unique biophysical and biochemical properties of intrinsically disordered proteins (IDPs) and their recombinant derivatives, intrinsically disordered protein polymers (IDPPs) offer opportunities for producing multistimuli-responsive materials; their sequence-encoded disorder and tendency for phase separation facilitate the development of multifunctional materials. This review highlights the strategies for enhancing the structural diversity of elastin-like polypeptides (ELPs) and resilin-like polypeptides (RLPs), and their self-assembled structures via genetic fusion to ordered motifs such as helical or beta sheet domains. In particular, this review describes approaches that harness the synergistic interplay between order-promoting and thermoresponsive building blocks to design hybrid biomaterials, resulting in well-structured, stimuli-responsive supramolecular materials ordered on the nanoscale.
无规蛋白（IDPs）及其重组衍生物——无规蛋白聚合物（IDPPs）具有独特的物理化学性质，为生产多刺激响应材料提供了机会；它们的序列编码无序和相分离倾向促进了多功能材料的发展。本综述重点介绍了通过与有序结构域（如螺旋或β-折叠结构域）的基因融合来增强弹性蛋白样多肽（ELPs）和松弛素样多肽（RLPs）及其自组装结构的结构多样性的策略。特别是，本综述描述了利用促进有序和热响应构建模块之间的协同相互作用来设计杂化生物材料的方法，从而得到结构良好、对刺激有响应的纳米级有序超分子材料。
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