Guangdong Provincial Animal Virus Vector Vaccine Engineering Technology Research Center, College of Animal Science, South China Agricultural University, Guangzhou 510642, PR China.
Wen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Xinxing, Guangdong 527400, PR China.
Vet Microbiol. 2024 May;292:110053. doi: 10.1016/j.vetmic.2024.110053. Epub 2024 Mar 11.
Infectious bursal disease virus (IBDV) caused an acute and highly contagious infectious disease characterized by severe immunosuppression, causing considerable economic losses to the poultry industry globally. Although this disease was well-controlled under the widely use of commercial vaccines in the past decades, the novel variant IBDV strains emerged recently because of the highly immunized-selection pressure in the field, posting new threats to poultry industry. Here, we reported novel variant IBDV is responsible for a disease outbreak, and assessed the epidemic and pathogenicity of IBDV in this study. Moreover, we constructed a challenge model using Fowl adenovirus serotype 4 (FAdV-4) to study on the immunosuppressive effect. Our findings underscore the importance of IBDV surveillance, and provide evidence for understanding the pathogenicity of IBDV.
传染性腔上囊病病毒（IBDV）引起一种急性和高度接触传染性疾病，其特征为严重的免疫抑制，给全球家禽业造成了相当大的经济损失。尽管在过去几十年中，由于该疾病在田间受到广泛的商业疫苗免疫选择压力，新型变异 IBDV 株的出现构成了对家禽业的新威胁，但该疾病在过去几十年中得到了很好的控制。在这里，我们报道了新型变异 IBDV 是疾病暴发的原因，并在本研究中评估了 IBDV 的流行和致病性。此外，我们使用禽腺病毒血清型 4（FAdV-4）构建了一个挑战模型，以研究其免疫抑制作用。我们的研究结果强调了 IBDV 监测的重要性，并为了解 IBDV 的致病性提供了证据。
