Centers for Disease Control and Prevention, Atlanta, Georgia.
Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee.
J Registry Manag. 2023 Winter;50(4):116-121.
Scrotal squamous cell carcinomas (SCCs) are rare malignancies that are not considered to be associated with the human papillomavirus (HPV) by the International Agency for Research on Cancer. However, recent studies have detected HPV in these cancers. We sought to determine the presence of HPV types among scrotal cancer cases identified through population-based cancer registries.
Primary scrotal SCCs diagnosed from 2014 to 2015 were identified, and tissue sections from formalin-fixed, paraffin-embedded tissue blocks were obtained for laboratory testing. A pathology review was performed to confirm morphology. HPV testing was performed using L1 consensus polymerase chain reaction analysis. Immunohistochemistry was used to evaluate p16INK4a (p16) expression.
Five cases of scrotal SCC were identified from 1 cancer registry. Age at diagnosis ranged from 34 to 75 years (median, 56 years). Four cases were non-Hispanic White, and 1 was non-Hispanic Black. The morphologic subtype of 4 cases was keratinizing (usual), and 1 case was verrucous (warty) histologic subtype. Two of the usual cases of SCC were HPV-negative and p16-negative, and 2 were positive for HPV16 and p16. The verrucous (warty) SCC subtype case was HPV6-positive and p16-negative.
The presence of HPV16 and p16 overexpression in the examined tissue specimens lends additional support for the role of HPV in the etiology of scrotal SCC.
阴囊鳞状细胞癌（SCC）是一种罕见的恶性肿瘤，国际癌症研究机构认为其与人类乳头瘤病毒（HPV）无关。然而，最近的研究已经在这些癌症中检测到 HPV。我们试图确定通过基于人群的癌症登记处确定的阴囊癌病例中 HPV 类型的存在。
从 2014 年至 2015 年确定了原发性阴囊 SCC，并获得了来自福尔马林固定、石蜡包埋组织块的组织切片进行实验室检测。进行了病理审查以确认形态。使用 L1 共识聚合酶链反应分析进行 HPV 检测。使用免疫组化评估 p16INK4a（p16）表达。
从 1 个癌症登记处确定了 5 例阴囊 SCC。诊断时的年龄范围为 34 至 75 岁（中位数，56 岁）。4 例为非西班牙裔白人，1 例为非西班牙裔黑人。4 例形态亚型为角化（寻常型），1 例为疣状（疣状）组织学亚型。2 例寻常型 SCC 为 HPV 阴性和 p16 阴性，2 例为 HPV16 和 p16 阳性。疣状（疣状）SCC 亚型病例 HPV6 阳性且 p16 阴性。
在检查的组织标本中存在 HPV16 和 p16 过表达，这进一步支持 HPV 在阴囊 SCC 病因学中的作用。
