Tian Yu, Yao Guanqun, Skudder-Hill Loren, Xu Guangyang, Qian Yuxuan, Tang Feng, Wang Qian, Bao Qianhui, Li Lei
Vascular Surgery Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.
School of Clinical Medicine, Tsinghua University, Beijing, China.
Front Microbiol. 2024 Mar 5;15:1340262. doi: 10.3389/fmicb.2024.1340262. eCollection 2024.
The relationship between gut microbiota and peripheral artery disease (PAD) remains understudied. While traditional risk factors like smoking and hyperlipidemia are well-understood, our study aims to determine the potential causative association of gut microbiota with PAD using Mendelian Randomization.
Data from the International MiBioGen Consortium and the FinnGen research project were used to study 211 bacterial taxa. Instrumental variables, comprising 2079 SNPs, were selected based on significance levels and linkage disequilibrium. Analyses were conducted utilizing the inverse-variance weighted (IVW) method and other statistical MR techniques to mitigate biases, processed in R (v4.3.1) with the TwosampleMR package.
Three bacterial taxa, namely genus , , and , emerged as protective factors against PAD. In contrast, family. FamilyXI and the genus and were identified as risk factors.
Our findings hint at a causative association between certain gut microbiota and PAD, introducing new avenues for understanding PAD's etiology and developing effective treatments. The observed associations now warrant further validation in varied populations and detailed exploration at finer taxonomic levels.
肠道微生物群与外周动脉疾病（PAD）之间的关系仍未得到充分研究。虽然吸烟和高脂血症等传统风险因素已为人熟知，但我们的研究旨在利用孟德尔随机化确定肠道微生物群与PAD之间潜在的因果关联。
来自国际微生物基因组联盟和芬兰基因研究项目的数据用于研究211个细菌分类群。基于显著性水平和连锁不平衡选择了包含2079个单核苷酸多态性（SNP）的工具变量。使用逆方差加权（IVW）方法和其他统计孟德尔随机化技术进行分析以减轻偏差，在R（v4.3.1）中使用双样本MR包进行处理。
三个细菌分类群，即属 、 和 ，成为PAD的保护因素。相比之下，科 、科XI以及属 和 被确定为风险因素。
我们的研究结果表明某些肠道微生物群与PAD之间存在因果关联，为理解PAD的病因和开发有效治疗方法开辟了新途径。目前观察到的关联值得在不同人群中进一步验证，并在更精细的分类水平上进行详细探索。
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