Wei Yi, Lu Xuechao, Liu Chao
Department of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Respiratory and Critical Care Medicine, Qingdao Traditional Chinese Medicine Hospital (Qingdao Hiser Hospital), Qingdao, China.
Front Microbiol. 2023 Jun 19;14:1196751. doi: 10.3389/fmicb.2023.1196751. eCollection 2023.
A growing number of studies implies a strong association between gut microbiota and chronic obstructive pulmonary disease (COPD). However, the causal impact between gut microbiota and COPD remains unclear. As a result, we used a two-sample Mendelian randomization (MR) method to investigate the connection between gut microbiota and COPD in this study.
The largest available genome-wide association study (GWAS) of gut microbiota was obtained from the MiBioGen consortium. Summary-level dataset for COPD were obtained from the FinnGen consortium. The main analysis method for determining the causal link between gut microbiota and COPD was inverse variance weighted (IVW). Subsequently, pleiotropy and heterogeneity tests were performed to determine the reliability of the results.
IVW method identified 9 bacterial taxa nominally associated with the risk of COPD. Class Actinobacteria ( = 0.020), genus ( = 0.024), genus ( = 0.002) and genus ( = 0.018) were protective against COPD. In addition, order Desulfovibrionales ( = 0.011), family Desulfovibrionaceae ( = 0.039), family Peptococcaceae ( = 0.020), family Victivallaceae ( = 0.012) and genus ( = 0.017) were associated with a higher risk of COPD. No pleiotropy or heterogeneity were found.
According to the findings of this MR analysis, a causal relationship exists between certain gut microbiota and COPD. New insights into the mechanisms of COPD mediated by gut microbiota are provided.
越来越多的研究表明肠道微生物群与慢性阻塞性肺疾病（COPD）之间存在密切关联。然而，肠道微生物群与COPD之间的因果关系仍不明确。因此，在本研究中我们采用两样本孟德尔随机化（MR）方法来探究肠道微生物群与COPD之间的联系。
肠道微生物群的最大可用全基因组关联研究（GWAS）来自MiBioGen联盟。COPD的汇总水平数据集来自芬兰基因组计划（FinnGen）联盟。确定肠道微生物群与COPD之间因果关系的主要分析方法是逆方差加权（IVW）。随后，进行了多效性和异质性检验以确定结果的可靠性。
IVW方法确定了9个细菌分类群与COPD风险名义上相关。放线菌纲（=0.020）、属（=0.024）、属（=0.002）和属（=0.018）对COPD具有保护作用。此外，脱硫弧菌目（=0.011）、脱硫弧菌科（=0.039）、消化球菌科（=0.020）、维氏菌科（=0.012）和属（=0.017）与COPD的较高风险相关。未发现多效性或异质性。
根据这项MR分析的结果，某些肠道微生物群与COPD之间存在因果关系。为肠道微生物群介导的COPD机制提供了新的见解。
