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Identification of T-kininogen in high and low molecular weight kininogens deficient rat (brown Norway Katholiek strain).

作者信息

Hayashi I, Oh-ishi S, Kato H, Enjyoji K, Iwanaga S, Nakano T

出版信息

Thromb Res. 1985 Aug 1;39(3):313-21. doi: 10.1016/0049-3848(85)90227-0.

DOI:10.1016/0049-3848(85)90227-0
PMID:3850646
Abstract

Kinin release in Brown Norway Katholiek (B/N-Ka) rat plasma was compared with those of Brown Norway Kitasato and Sprague-Dawley rats by treating with rat plasma kallikrein, rat urinary kallikrein, snake venom kininogenase and trypsin. B/N-Ka rat plasma yielded no detectable amount of kinin by either plasma kallikrein, urinary kallikrein or snake venom kininogenase, but yielded variable amount of kinin by trypsin. The released kinin was proved to be isoleucylseryl-bradykinin by high performance liquid chromatography and bioassay profiles. B/N-Ka rat plasma formed a precipitation line against antiserum to T-kininogen, but no line against antiserum to HMW kininogen-light chain.

摘要

相似文献

1
Identification of T-kininogen in high and low molecular weight kininogens deficient rat (brown Norway Katholiek strain).
Thromb Res. 1985 Aug 1;39(3):313-21. doi: 10.1016/0049-3848(85)90227-0.
2
Demonstration of the third kininogen in high and low molecular weight kininogens-deficient Brown Norway Katholiek rat.
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Demonstration of derivation of rat urinary bradykinin from plasma low-molecular-weight kininogen: a study using kininogen-deficient rats.
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Functionally active high molecular weight-kininogen was found in the liver, but not in the plasma of brown Norway Katholiek rat.在棕色挪威天主教大鼠的肝脏中发现了功能活性高分子量激肽原，但在其血浆中未发现。
Thromb Res. 1989 Oct 15;56(2):179-89. doi: 10.1016/0049-3848(89)90160-6.
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Kininogen deficiency in the rat.大鼠激肽原缺乏症。
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8
Direct radioimmunoassay for rat high molecular weight kininogen. Measurement of immunoreactive high molecular weight kininogen in normal and kininogen deficient plasma.
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Hydrolysis of rat high molecular weight kininogen by purified rat urinary kallikrein: identification of bradykinin as the kinin formed.纯化的大鼠尿激肽释放酶对大鼠高分子量激肽原的水解作用：鉴定缓激肽为所形成的激肽。
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Further characterization of monoclonal antibodies against rat plasma kallikrein, rat low molecular weight kininogen and synthetic bradykinin.针对大鼠血浆激肽释放酶、大鼠低分子量激肽原和合成缓激肽的单克隆抗体的进一步特性研究。
Adv Exp Med Biol. 1989;247B:223-30. doi: 10.1007/978-1-4615-9546-5_37.

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