Nilave Niaz, Nahid Sajida, Karim Saiyeda, Islam Shahnoor, Morshed Amirul
Department of Cardio Vascular Surgery Dhaka Medical College Dhaka, Bangladesh 373/25 Free School Street Hatirpool, Dhaka, Bangladesh.
Department of Radiology and Imaging Dhaka Medical College, Dhaka, Bangladesh.
J Pediatr Surg. 2024 Aug;59(8):1615-1618. doi: 10.1016/j.jpedsurg.2024.02.026. Epub 2024 Feb 27.
Wilms' tumor is the most common renal tumor in children.
To correlate the percentage of necrosis and tumor volume change found in preoperative Contrast Enhance Computed Tomography (CECT) scan of the abdomen with post-operative histopathological findings of Wilms Tumor (WT).
In this prospective study from January 2020 to December 2022, out of 33 patients, 15 patients with unilateral localized WT (stage I, II, and III) treated according to SIOP UMBRELLA protocol 2016 were included. Bilateral, syndromic, and stage IV WT were excluded. The radiological response was measured in preoperative CECT by estimating the percentage of necrosis found in static images and compared with post-operative histopathological findings. Tumor volume changes were measured by comparing CECT at diagnosis and following chemotherapy. Tumor volume change was also compared with histology.
There was a significant positive correlation between radiological response to necrosis with histology as per Pearson correlation. Significant positive correlation also found between volume changes on pre and post chemotherapy CECT with histology as per Spearman correlation.
The changes in tumors during preoperative radiological evaluation and histologically confirmed necrosis are strongly related.
肾母细胞瘤是儿童最常见的肾肿瘤。
将腹部术前增强计算机断层扫描（CECT）中发现的坏死百分比和肿瘤体积变化与肾母细胞瘤（WT）的术后组织病理学结果相关联。
在这项2020年1月至2022年12月的前瞻性研究中，33例患者中，15例根据SIOP UMBRELLA 2016方案治疗的单侧局限性WT（I、II和III期）患者被纳入。双侧、综合征性和IV期WT被排除。术前CECT通过估计静态图像中发现的坏死百分比来测量放射学反应，并与术后组织病理学结果进行比较。通过比较诊断时和化疗后的CECT来测量肿瘤体积变化。肿瘤体积变化也与组织学进行比较。
根据Pearson相关性分析，放射学坏死反应与组织学之间存在显著正相关。根据Spearman相关性分析，化疗前后CECT的体积变化与组织学之间也存在显著正相关。
术前放射学评估期间肿瘤的变化与组织学证实的坏死密切相关。
