Hurzeler Tristan, Watt Joshua, Logge Warren, Towers Ellen, Suraev Anastasia, Lintzeris Nicholas, Haber Paul, Morley Kirsten C
Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Translational Research in Alcohol, Edith Collins Centre, Sydney Local Health District, Sydney, Australia.
J Cannabis Res. 2024 Mar 21;6(1):15. doi: 10.1186/s42238-024-00224-0.
The underlying neurobiological mechanisms of cannabidiol's (CBD) management of alcohol use disorder (AUD) remains elusive.Aim We conducted a systematic review of neuroimaging literature investigating the effects of CBD on the brain in healthy participants. We then theorise the potential neurobiological mechanisms by which CBD may ameliorate various symptoms of AUD.Methods This review was conducted according to the PRISMA guidelines. Terms relating to CBD and neuroimaging were used to search original clinical research published in peer-reviewed journals.Results Of 767 studies identified by our search strategy, 16 studies satisfied our eligibility criteria. The results suggest that CBD modulates γ-Aminobutyric acid and glutamate signaling in the basal ganglia and dorso-medial prefrontal cortex. Furthermore, CBD regulates activity in regions associated with mesocorticolimbic reward pathways; salience, limbic and fronto-striatal networks which are implicated in reward anticipation; emotion regulation; salience processing; and executive functioning.Conclusion CBD appears to modulate neurotransmitter systems and functional connections in brain regions implicated in AUD, suggesting CBD may be used to manage AUD symptomatology.
大麻二酚（CBD）对酒精使用障碍（AUD）的潜在神经生物学机制仍不清楚。目的我们对神经影像学文献进行了系统综述，研究CBD对健康参与者大脑的影响。然后，我们对CBD可能改善AUD各种症状的潜在神经生物学机制进行了理论推测。方法本综述按照PRISMA指南进行。使用与CBD和神经影像学相关的术语检索发表在同行评审期刊上的原始临床研究。结果通过我们的检索策略识别出的767项研究中，16项研究符合我们的纳入标准。结果表明，CBD调节基底神经节和背内侧前额叶皮质中的γ-氨基丁酸和谷氨酸信号传导。此外，CBD调节与中脑边缘奖赏通路、与奖赏预期、情绪调节、显著性处理和执行功能有关的显著性、边缘和额纹状体网络相关区域的活动。结论CBD似乎调节了与AUD相关的脑区中的神经递质系统和功能连接，表明CBD可用于管理AUD症状。
