Zhou Wei, Tang MengYue, Sun Ling, Lin HongYu, Tan Ying, Fan Yang, Fan Si, Zhang ShuShan
Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Maoyuan South Street 1, Nanchong, Sichuan 637000, PR China.
Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Maoyuan South Street 1, Nanchong, Sichuan 637000, PR China.
IBRO Neurosci Rep. 2024 Mar 6;16:436-442. doi: 10.1016/j.ibneur.2024.03.001. eCollection 2024 Jun.
Parkinson's Disease (PD) and Drug-induced parkinsonism (DIP) are the most common subtypes of parkinsonism, yet no studies have reported that the subcortical volume alterations in DIP patients. This study aimed to identify specific alterations of subcortical structures volume in DIP patients, and investigate association between the subcortical structure modifications and clinical symptoms. We recruited 27 PD patients, 25 DIP patients and 30 healthy controls (HCs). The clinical symptom-related parameters (Unified Parkinson's Disease Rating Scale, UPDRS) were evaluated. Structural imaging was performed on a 3.0 T scanner, and volumes of subcortical structures were obtained using FreeSurfer software. Analysis of covariance (ANCOVA) and partial correlation analysis were performed. DIP group had significantly smaller volume of the thalamus, pallidum, hippocampus and amygdala compared to HCs. ROC curve analysis demonstrated that the highest area under curve (AUC) value was in the right pallidum (AUC = 0.831) for evaluating the diagnostic efficacy in DIP from HCs. Moreover, the volumes of the putamen, hippocampus and amygdala were negatively correlated with UPDRSII in the DIP patients. The volume of the amygdala was negatively correlated with UPDRSIII. The present study provides novel information regarding neuroanatomical alteration of subcortical nuclei in DIP patients, suggesting that these methods might provide the basis for early diagnosis and differential diagnosis of DIP.
帕金森病（PD）和药物性帕金森综合征（DIP）是帕金森综合征最常见的亚型，但尚无研究报道DIP患者的皮质下体积改变情况。本研究旨在确定DIP患者皮质下结构体积的特定改变，并探讨皮质下结构改变与临床症状之间的关联。我们招募了27例PD患者、25例DIP患者和30名健康对照者（HCs）。评估了与临床症状相关的参数（统一帕金森病评定量表，UPDRS）。在3.0 T扫描仪上进行结构成像，并使用FreeSurfer软件获取皮质下结构的体积。进行了协方差分析（ANCOVA）和偏相关分析。与HCs相比，DIP组的丘脑、苍白球、海马和杏仁核体积明显较小。ROC曲线分析表明，在评估DIP与HCs的诊断效能时，右侧苍白球的曲线下面积（AUC）值最高（AUC = 0.831）。此外，在DIP患者中，壳核、海马和杏仁核的体积与UPDRSII呈负相关。杏仁核的体积与UPDRSIII呈负相关。本研究提供了有关DIP患者皮质下核神经解剖学改变的新信息，表明这些方法可能为DIP的早期诊断和鉴别诊断提供依据。
