Xu Jialing, Zhang Hao, Chen Dan, Xu Kaiyong, Li Zifa, Wu Hongyun, Geng Xiwen, Wei Xia, Wu Jibiao, Cui Wenqiang, Wei Sheng
The Key Laboratory of Traditional Chinese Medicine Classic Theory of Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People's Republic of China.
Chinese Medicine and Brain Science Interdisciplinary Research Institute, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People's Republic of China.
J Pain Res. 2024 Mar 16;17:1091-1105. doi: 10.2147/JPR.S455549. eCollection 2024.
Chronic pain (CP) is a leading cause of disability and a potential factor that affects biological processes, family relationships, and self-esteem of patients. However, the need for treatment of CP is presently unmet. Current methods of pain management involve the use of drugs, but there are different degrees of concerning side effects. At present, the potential mechanisms underlying CP are not completely clear. As research progresses and novel therapeutic approaches are developed, the shortcomings of current pain treatment methods may be overcome. In this review, we discuss the retinal photoreceptors and brain regions associated with photoanalgesia, as well as the targets involved in photoanalgesia, shedding light on its potential underlying mechanisms. Our aim is to provide a foundation to understand the mechanisms underlying CP and develop light as a novel analgesic treatment has its biological regulation principle for CP. This approach may provide an opportunity to drive the field towards future translational, clinical studies and support pain drug development.
慢性疼痛（CP）是导致残疾的主要原因，也是影响患者生物过程、家庭关系和自尊的潜在因素。然而，目前对CP治疗的需求尚未得到满足。当前的疼痛管理方法包括使用药物，但存在不同程度的副作用问题。目前，CP潜在的机制尚不完全清楚。随着研究的进展和新治疗方法的开发，当前疼痛治疗方法的缺点可能会被克服。在这篇综述中，我们讨论了与光镇痛相关的视网膜光感受器和脑区，以及光镇痛涉及的靶点，以揭示其潜在的机制。我们的目的是为理解CP的潜在机制提供基础，并将光作为一种新型镇痛治疗方法，因为它对CP有其生物调节原理。这种方法可能为推动该领域未来的转化临床研究以及支持疼痛药物开发提供机会。
