Department of Periodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Oral Medicine and Periodontology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Biomed Res Int. 2024 Mar 13;2024:6997142. doi: 10.1155/2024/6997142. eCollection 2024.
Menopause is typically accompanied by significant systemic and oral manifestations, including hormonal changes and increased susceptibility to periodontal disease, which may involve inflammatory biomarkers like aspartate aminotransferase (AST) and osteocalcin in gingival crevicular fluid (GCF). The study is aimed at evaluating the effectiveness of regular inoculation of polyunsaturated fatty acids (PUFAs) as an adjunctive treatment for menopausal women's periodontitis.
Twenty elderly women with chronic periodontitis were split evenly into two groups by random assignment. Patients in group II (the research group) were given soft gelatin capsules containing PUFAs to be consumed directly once daily for 12 months, as opposed to group I (the control group), who received soft gelatin capsules containing some olive oil (placebo). Scaling and root planning (SRP) were used to address periodontal disease in all cases.
At baseline, six and twelve months after treatment, clinical indicators and AST and osteocalcin amounts in the GCF were noted. By the conclusion of the research period, all observed clinical measurements had changed significantly and improved. In addition, there had been a significant decrease in AST levels and a nonsignificant decrease in osteocalcin levels in group II compared to group I.
Menopausal women with periodontitis who take omega-3 fatty acid supplements in addition to SRP have better oral health. Significant improvements in clinical indicators and a notable decrease in AST levels within the GCF were observed. However, further research with larger cohorts and extended duration is needed to validate these findings and explain potential mechanisms. This trial is registered with NCT06254118.
绝经通常伴随着显著的全身和口腔表现，包括激素变化和牙周病易感性增加，这可能涉及到牙龈沟液（GCF）中的天门冬氨酸氨基转移酶（AST）和骨钙素等炎症生物标志物。本研究旨在评估定期接种多不饱和脂肪酸（PUFAs）作为绝经后妇女牙周炎辅助治疗的有效性。
通过随机分组，将 20 名患有慢性牙周炎的老年女性平均分为两组。第 II 组（研究组）患者每天直接服用含有 PUFAs 的软明胶胶囊 12 个月，而第 I 组（对照组）患者服用含有一些橄榄油（安慰剂）的软明胶胶囊。所有病例均采用牙周刮治和根面平整术（SRP）治疗牙周病。
在基线、治疗 6 个月和 12 个月时，记录了临床指标以及 GCF 中的 AST 和骨钙素含量。在研究结束时，所有观察到的临床测量值均发生了显著变化并得到了改善。此外，与第 I 组相比，第 II 组的 AST 水平显著降低，而骨钙素水平略有降低，但无统计学意义。
除了 SRP 之外，患有牙周炎的绝经后妇女服用欧米伽-3 脂肪酸补充剂可以改善口腔健康。观察到临床指标显著改善，GCF 中的 AST 水平明显降低。然而，需要进一步研究更大的队列和更长的时间来验证这些发现并解释潜在的机制。本试验已在 NCT06254118 注册。
