Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India.
School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, India.
Int J Dermatol. 2024 Jul;63(7):858-872. doi: 10.1111/ijd.17081. Epub 2024 Mar 21.
Dermatomycosis or superficial mycosis is considered one of the chronic fungal infections and a global challenge for the public health system. The severity of dermatomycosis is proportionately increasing with the emerging population of immunocompromised individuals, and it is becoming more prevalent, even life-threatening, in several tropical countries. In this context, improper long-term treatment with synthetic antifungal drugs and their related side effects imposes additional challenges in treating dermatomycosis. Thus, the present scenario highlights the need for a novel and accurate treatment with minimal or no side effects. The multifaceted therapeutic properties of various natural products have garnered the interest of scientific communities in recent years. Generally, plant-based products have low toxicity levels and offer diverse formulations and unique biomolecules for clinical applicability against dermatomycosis. Thus, this study presents an overview of the pathogenesis and different treatment strategies for dermatomycosis. In addition, we highlight the implementation of natural products of plant origin for treating dermatomycosis infections and reducing adverse events. Further, their mode of action and role in the development of pharmaceutical drugs are discussed.
皮肤真菌病或浅部真菌病被认为是慢性真菌感染之一，也是公共卫生系统面临的全球性挑战。随着免疫功能低下人群的不断增加，皮肤真菌病的严重程度也相应增加，在一些热带国家，它变得更加普遍，甚至危及生命。在这种情况下，长期使用合成抗真菌药物治疗不当及其相关副作用给治疗皮肤真菌病带来了额外的挑战。因此，目前的情况凸显了需要一种新型、准确、副作用最小或没有的治疗方法。近年来，各种天然产物的多方面治疗特性引起了科学界的兴趣。一般来说，植物类产品的毒性水平较低，并且为临床应用提供了多样化的制剂和独特的生物分子，以对抗皮肤真菌病。因此，本研究概述了皮肤真菌病的发病机制和不同的治疗策略。此外，我们还强调了利用植物来源的天然产物治疗皮肤真菌病感染和减少不良反应的重要性。此外，还讨论了它们的作用机制以及在药物开发中的作用。
