Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.
Center for Virology, Medical University of Vienna, Vienna, Austria.
J Med Virol. 2024 Mar;96(3):e29554. doi: 10.1002/jmv.29554.
Torque Teno virus (TTV) is nonpathogenic, highly prevalent, and reflects the immune status of its host. Thus, TTV plasma load was suggested for the guidance of immunosuppression post solid organ transplantation. The present study was designed to determine the kinetics of TTV following changes in calcineurin inhibitor (CNI) dose. A total of 48 adult recipients of a kidney graft transplanted at the Medical University of Vienna between 2018 and 2019 with isolated changes in CNI dose were selected from the prospective TTV-POET trial. TTV plasma load was quantified by in-house PCR. At Day 30 following CNI dose adaptation (median 33% of daily dose) no changes in TTV load were noted. However, at Day 60, following CNI dose reduction a lower TTV load of 6.4 log c/mL (median; interquartile range [IQR] 4.9-8.1) compared with the baseline of 7.1 log c/mL (IQR 5.3-8.9) was noted (p = 0.001); there was also a trend toward a higher TTV load following CNI increase (6.6 log c/mL, IQR 4.1-9.7 vs. 5.2 log c/mL, IQR 4.5-6.8; p = 0.09). The data suggested that TTV load changes become noticeable only 2 months after CNI dose adaptation, which might be the ideal time point for TTV load monitoring.
Torque Teno 病毒（TTV）无致病性、高度普遍存在，并反映其宿主的免疫状态。因此，TTV 血浆载量被建议用于指导实体器官移植后的免疫抑制。本研究旨在确定钙调神经磷酸酶抑制剂（CNI）剂量变化后 TTV 的动力学。从维也纳医科大学前瞻性 TTV-POET 试验中选择了 2018 年至 2019 年间接受肾脏移植的 48 名成人患者，这些患者的 CNI 剂量发生了单独变化。TTV 血浆载量通过内部 PCR 进行定量。在 CNI 剂量调整后第 30 天（中位剂量为每日剂量的 33%），TTV 载量没有变化。然而，在 CNI 剂量减少后第 60 天，与基线相比（7.1 log c/mL，IQR 5.3-8.9），TTV 载量较低，为 6.4 log c/mL（中位数；四分位距 [IQR] 4.9-8.1）（p = 0.001）；CNI 增加后 TTV 载量也呈上升趋势（6.6 log c/mL，IQR 4.1-9.7 与 5.2 log c/mL，IQR 4.5-6.8；p = 0.09）。数据表明，只有在 CNI 剂量调整后 2 个月，TTV 载量变化才变得明显，这可能是 TTV 载量监测的理想时间点。
