胶囊大小以及受检者年龄和性别对胶囊吞咽影响的视诊荧光检查评估。
VIDEOFLUOROSCOPIC EVALUATION OF THE IMPACT OF CAPSULE SIZE AND SUBJECT'S AGE AND GENDER ON CAPSULE SWALLOWING.
机构信息
Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Instituto de Reabilitação e Estudos em Fonoaudiologia - InReab, São Paulo, SP, Brasil.
出版信息
Arq Gastroenterol. 2024 Mar 15;61:e23092. doi: 10.1590/S0004-2803.246102023-92. eCollection 2024.
BACKGROUND
People recurrently have difficulties swallowing solid medications, which can be associated with the size of the medication and the age and gender of individuals.
OBJECTIVE
To evaluate the impact of capsule size and adults' age and gender on oral and pharyngeal capsule transit during capsule swallows.
METHODS
Videofluoroscopy was used to measure capsule oral and pharyngeal transit during swallows in 49 healthy individuals (17 men and 32 women), with a mean age of 46 years (ranging from 23 to 88 years). Smaller capsules were filled with 0.50 mL of barium sulfate, and larger capsules were filled with 0.95 mL of barium sulfate; the volume of liquid ingested with the capsules was also quantified in each ingestion. The measurements included the oral preparation time, oral transit time, swallowing reaction time, time to laryngeal vestibule closure, laryngeal vestibule closure duration, pharyngeal transit time, and upper esophageal sphincter opening duration.
RESULTS
The capsule size did not influence either the oral or pharyngeal transit time. Increased liquid volume was ingested with larger capsules and by people older than 40 years. The oral transit time was shorter in older adults (60-88 years), and the time to laryngeal vestibule closure was longer in women.
CONCLUSION
The size of large capsules did not make a difference in oral or pharyngeal transit when compared with smaller capsules. The capsule size and the participant's age influenced the volume of liquid ingested - larger capsules and older individuals required a larger volume. The capsule oral transit was faster in individuals older than 60 years.
BACKGROUND
•Swallowing is influenced by the characteristics of what is being swallowed.
BACKGROUND
•There was no difference in swallowing capsules containing 0.50 mL or 0.95 mL.
BACKGROUND
•Larger capsules need more liquid ingestion to make swallowing easier.
BACKGROUND
•Individuals older than 40 years need a greater volume of liquid to swallow capsules than younger adults.
背景
人们经常在吞咽固体药物时遇到困难，这可能与药物的大小以及个体的年龄和性别有关。
目的
评估胶囊大小以及成人年龄和性别对胶囊吞咽过程中口腔和咽部胶囊转运的影响。
方法
使用荧光透视法测量 49 名健康个体（17 名男性和 32 名女性）在吞咽胶囊期间的口腔和咽部胶囊转运，平均年龄为 46 岁（范围为 23 岁至 88 岁）。较小的胶囊填充 0.50 毫升硫酸钡，较大的胶囊填充 0.95 毫升硫酸钡；在每次摄入时还定量测量摄入的液体量。测量包括口腔准备时间、口腔转运时间、吞咽反应时间、声门裂关闭时间、声门裂关闭持续时间、咽部转运时间和食管上括约肌开放持续时间。
结果
胶囊大小均不影响口腔或咽部转运时间。较大的胶囊和年龄超过 40 岁的人摄入的液体量更多。老年人（60-88 岁）的口腔转运时间更短，女性的声门裂关闭时间更长。
结论
与较小的胶囊相比，大胶囊的大小在口腔或咽部转运中没有差异。胶囊大小和参与者的年龄影响液体摄入量-较大的胶囊和年龄较大的个体需要更大的体积。60 岁以上的个体胶囊口腔转运速度更快。
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