Segrestaa J M, Techenet J, Gueris J, Lamotte M
Sem Hop. 1979;55(13-14):698-710.
Prolactin has been lately singled-out among the pituitary hormones, and as such the object of considerable research in the past 15 years. The frequency of prolactin secreting adenomes is established now. The responsability of iatrogenic factors (neuroleptics, oral contraceptives) in some hyperprolactineamias is a known fact. The study of the inhibiting dopaminergic system was a landmark in the treatment of hyperprolactinaemia. During the recent Nice Congress, some issues remained unsettled on the physiological activities of prolactin. The matter is clearer when its comes to prolactin secretion. In equilibrium between inhibiting and stimulant factors, the secretion is controlled by the CNS, influenced by the hormonal environment, and its timing is the object of a retrocontrol. This is a very instructive pattern in endocrinology.
催乳素最近在垂体激素中被单独列出，因此在过去15年里成为了大量研究的对象。现在已经明确了催乳素分泌腺瘤的发生率。某些高催乳素血症中医源性因素（抗精神病药物、口服避孕药）的作用已是众所周知的事实。对多巴胺能抑制系统的研究是治疗高催乳素血症的一个里程碑。在最近的尼斯大会上，关于催乳素生理活性的一些问题仍未得到解决。当涉及到催乳素分泌时，情况就比较清楚了。在抑制性和刺激性因素之间保持平衡时，催乳素的分泌由中枢神经系统控制，受激素环境影响，其分泌时机受到反馈调节。这在内分泌学中是一个很有启发性的模式。
