Department of Periodontology, GRS Dental Clinic, Mayiladuthurai, Tamil Nadu, India, Phone: +91 9245196777, e-mail:
Department of Preventive Dentistry, College of Dentistry in Ar Rass, Qassim University, Al-Qassim, Kingdom of Saudi Arabia.
J Contemp Dent Pract. 2024 Feb 1;25(2):114-117. doi: 10.5005/jp-journals-10024-3642.
The study aims is to evaluate the antibacterial effect of vitamin D3 against the , in chronic periodontitis patients.
The study comprised 98 participants with chronic periodontitis. All clinical parameters including plaque index (PI), gingival bleeding index (GBI), probing pocket depth (PPD), clinical attachment level (CAL), and a microbiological assay of were assessed at the baseline. All study participants who underwent scaling and root planning were divided into two groups, A and B, each with 49 patients and only group B patients were advised to take vitamin D supplementation of 60,000 IU granules, once daily for 2 months. All the patients of both the groups were recalled at the end of 2nd month and all the clinical and microbiological parameters were reassessed.
After two months, there was a reduction in all the clinical markers in both groups, but the group B patients showed more improvement following non-surgical treatment vitamin D intake. There was also a statistical reduction in and following administration of vitamin D in group B patients compared to group A.
These discoveries proposed that vitamin D has a superb antimicrobial impact against red complex periodontal microbes and might be considered a promising compound in the counteraction of periodontal disease.
Vitamin D is considered to possess anti-inflammatory and antimicrobial activity, which may help to delay the progression of periodontitis. So, vitamin D3 can be used as a potential supplement that could be employed to stop the advancement of periodontal disease. How to cite this article: Govindharajulu R, Syed NK, Sukumaran B, . Assessment of the Antibacterial Effect of Vitamin D3 against Red Complex Periodontal Pathogens: A Microbiological Assay. J Contemp Dent Pract 2024;25(2):114-117.
本研究旨在评估维生素 D3 对慢性牙周炎患者中 的抗菌作用。
本研究纳入了 98 名慢性牙周炎患者。所有临床参数，包括菌斑指数（PI）、牙龈出血指数（GBI）、探诊袋深度（PPD）、临床附着水平（CAL）和 的微生物学检测，均在基线时进行评估。所有接受牙周洁治和根面平整的研究参与者被分为两组，A 组和 B 组，每组 49 例，仅 B 组患者被建议每日服用 60000IU 维生素 D 颗粒一次，持续 2 个月。两组患者均在第 2 个月结束时复诊，并重新评估所有临床和微生物学参数。
两个月后，两组患者的所有临床指标均有所下降，但 B 组患者在接受非手术治疗和维生素 D 摄入后表现出更明显的改善。与 A 组相比，B 组患者在给予维生素 D 后， 和 也有统计学上的减少。
这些发现表明，维生素 D 对红色复合体牙周微生物具有极好的抗菌作用，可能被认为是一种有前途的牙周病防治化合物。
维生素 D 被认为具有抗炎和抗菌活性，这可能有助于延缓牙周炎的进展。因此，维生素 D3 可用作一种潜在的补充剂，可用于阻止牙周病的进展。
Govindharajulu R, Syed NK, Sukumaran B,. Assessment of the Antibacterial Effect of Vitamin D3 against Red Complex Periodontal Pathogens: A Microbiological Assay. J Contemp Dent Pract 2024;25(2):114-117.
