Department of Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
Department of Emergency and Critical Care Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
Sci Rep. 2024 Mar 21;14(1):6829. doi: 10.1038/s41598-024-57508-x.
To investigate dysphagia after extubation in patients with severe coronavirus disease 2019 (COVID-19). We retrospectively examined patients with severe COVID-19 treated in our hospital between August 2021 and March 2022. Feeding outcomes were categorized into two groups-(1) total oral intake, and (2) difficulty in oral intake. To assess the feeding outcome, we used modified water-swallowing test (MWST) for all patients. However, in cases where aspiration or recurrent laryngeal nerve palsy was suspected, we conducted the fiberoptic endoscopic evaluation of swallowing after MWST. Patient data were collected from medical records. Forty-six patients with severe COVID-19 were included. Among the 46 patients, 14 (30.4%) experienced difficulties with oral intake. Older age, longer length of hospitalization, duration of mechanical ventilation, tracheostomy, diabetes, and higher serum levels of C-reactive protein (CRP) and procalcitonin (PCT) at the time of intubation were associated with difficulty in oral intake. The rate of difficulty with oral intake in patients with severe COVID-19 was 30.4%, which is not as high as reported in previous studies. Older age, longer duration of mechanical ventilation, tracheostomy, diabetes, and higher levels of CRP and PCT were associated with the prevalence of oral intake difficulty, suggesting that early attention should be paid to high-risk patients who have preexisting deterioration of swallowing function due to aging and comorbidities, or who have prolonged intubation or tracheostomy to prevent aspiration pneumonia.
调查 2019 年冠状病毒病(COVID-19)重症患者拔管后吞咽困难。我们回顾性分析了 2021 年 8 月至 2022 年 3 月在我院治疗的重症 COVID-19 患者。将喂养结局分为两组:(1)完全经口进食;(2)经口摄食困难。为评估喂养结局,我们对所有患者使用改良饮水试验(MWST)。然而,对于怀疑有吸入或喉返神经麻痹的患者,我们在 MWST 后进行纤维内镜吞咽评估。患者数据从病历中收集。共纳入 46 例重症 COVID-19 患者。在这 46 例患者中,14 例(30.4%)存在经口摄食困难。年龄较大、住院时间较长、机械通气时间较长、气管切开术、糖尿病以及插管时血清 C 反应蛋白(CRP)和降钙素原(PCT)水平较高与经口摄食困难有关。重症 COVID-19 患者经口摄食困难的发生率为 30.4%,低于以往研究报道。年龄较大、机械通气时间较长、气管切开术、糖尿病以及 CRP 和 PCT 水平较高与经口摄食困难的发生有关,提示应早期关注因衰老和合并症导致吞咽功能恶化、或因长时间插管或气管切开术而有发生吸入性肺炎风险的高危患者。