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日本幽门螺杆菌感染阴性胃癌的临床病理及内镜特征：一项回顾性研究

Clinicopathological and endoscopic features of Helicobacter pylori infection-negative gastric cancer in Japan: a retrospective study.

作者信息

Imamura Kentaro, Yao Kenshi, Nimura Satoshi, Kanemitsu Takao, Miyaoka Masaki, Ono Yoichiro, Ueki Toshiharu, Tanabe Hiroshi

机构信息

Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.

Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.

出版信息

Clin Endosc. 2024 Jul;57(4):486-494. doi: 10.5946/ce.2023.258. Epub 2024 Mar 22.

DOI:10.5946/ce.2023.258
PMID:38514987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11294854/
Abstract

BACKGROUND/AIMS: Helicobacter pylori infection-negative gastric cancer (HPNGC) has not been systematically investigated in consecutive patients. Hence, this study aimed to investigate the clinicopathological and endoscopic features of HPNGC.

METHODS

This single-center retrospective study selected participants from patients with gastric cancer who were treated at the Fukuoka University Chikushi Hospital between January 2013 and December 2021. Only patients diagnosed with HPNGC were enrolled, and their clinicopathological and endoscopic features were analyzed in detail.

RESULTS

The prevalence of HPNGC in the present study was 2.6% (54/2112). The types of HPNGC observed in each gastric region were as follows: advanced gastric cancer was observed in the cardia; gastric adenocarcinoma of fundic-gland differentiation, gastric adenocarcinoma of foveolar-type presenting with whitish elevation and raspberry-like foveolar-type gastric adenocarcinoma, gastric adenocarcinoma arising in polyposis, and gastric adenocarcinoma with autoimmune gastritis were observed in the fundic gland region ranging from the gastric fornix to the gastric body; signet-ring cell carcinoma was observed in the gastric-pyloric transition region ranging from the lower gastric body to the gastric angle; and well-differentiated tubular adenocarcinoma with low-grade atypia was observed in the antrum.

CONCLUSIONS

This study revealed that tumors from each gastric region exhibited distinct macroscopic and histological types in HPNGC.

摘要

背景/目的：尚未对连续的患者进行幽门螺杆菌感染阴性胃癌（HPNGC）的系统研究。因此，本研究旨在探讨HPNGC的临床病理和内镜特征。

方法

本单中心回顾性研究选取了2013年1月至2021年12月在福冈大学筑紫医院接受治疗的胃癌患者。仅纳入诊断为HPNGC的患者，并对其临床病理和内镜特征进行详细分析。

结果

本研究中HPNGC的患病率为2.6%（54/2112）。在每个胃区域观察到的HPNGC类型如下：贲门部观察到进展期胃癌；在从胃穹窿到胃体的胃底腺区域观察到胃底腺分化型胃腺癌、呈现白色隆起的小凹型胃腺癌、覆盆子样小凹型胃腺癌、息肉病中发生的胃腺癌以及自身免疫性胃炎相关胃腺癌；在从胃体下部到胃角的胃幽门移行区域观察到印戒细胞癌；在胃窦部观察到低级别异型性的高分化管状腺癌。

结论

本研究表明，在HPNGC中，每个胃区域的肿瘤表现出不同的大体和组织学类型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/d50a5ec18d58/ce-2023-258f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/fcb9491277f2/ce-2023-258f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/a113182d8ebb/ce-2023-258f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/11ef51b1bc11/ce-2023-258f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/89ad34cb827a/ce-2023-258f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/30bf788c0781/ce-2023-258f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/77caf025aade/ce-2023-258f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/d50a5ec18d58/ce-2023-258f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/fcb9491277f2/ce-2023-258f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/a113182d8ebb/ce-2023-258f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/11ef51b1bc11/ce-2023-258f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/89ad34cb827a/ce-2023-258f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/30bf788c0781/ce-2023-258f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/77caf025aade/ce-2023-258f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae2/11294854/d50a5ec18d58/ce-2023-258f7.jpg

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