Mizuike Aya, Hanada Kentaro
Department of Quality Assurance, Radiation Safety and Information System, National Institute of Infectious Diseases, Tokyo, Japan.
Contact (Thousand Oaks). 2024 Mar 20;7:25152564241239443. doi: 10.1177/25152564241239443. eCollection 2024 Jan-Dec.
Phosphatidylinositol 4-monophosphate (PtdIns(4)P) is one of the key membrane components which mark the membrane contact sites. In the mammalian Golgi complex, PtdIns(4)P is produced at various subregions via specific mechanisms for each site. Particularly, PtdIns(4)P pools generated at the distal Golgi regions are pivotal for the determination of membrane contacts between the endoplasmic reticulum (ER) and Golgi, at which inter-organelle lipid transport takes place. In this short review, we will focus on C10orf76 (or ARMH3), which we propose to rename as DGARM after a distal Golgi armadillo repeat protein, for its function in generating a PtdIns(4)P pool crucial for ER-to-distal Golgi ceramide transport. We further discuss from the viewpoint of the evolutionary conservation of DGARM.
磷脂酰肌醇4-单磷酸（PtdIns(4)P）是标记膜接触位点的关键膜成分之一。在哺乳动物高尔基体复合体中，PtdIns(4)P通过针对每个位点的特定机制在各个亚区域产生。特别是，在高尔基体远端区域产生的PtdIns(4)P池对于内质网（ER）和高尔基体之间膜接触的确定至关重要，细胞器间脂质转运在此发生。在这篇简短的综述中，我们将重点关注C10orf76（或ARMH3），我们建议将其重新命名为DGARM，即远端高尔基体犰狳重复蛋白，因为它在生成对从内质网到远端高尔基体神经酰胺转运至关重要的PtdIns(4)P池中发挥作用。我们还从DGARM的进化保守性角度进行了进一步讨论。
