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Deletion of in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice.

作者信息

Yi Dan, Jin Hongting, Lu William W, Zhang Chunxiang, Xiao Guozhi, Tong Liping, Chen Di

机构信息

Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.

Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.

出版信息

Genes Dis. 2023 Oct 19;11(4):101147. doi: 10.1016/j.gendis.2023.101147. eCollection 2024 Jul.

DOI:10.1016/j.gendis.2023.101147
PMID:38515941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10955195/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e80/10955195/343433888b1e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e80/10955195/343433888b1e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e80/10955195/343433888b1e/gr1.jpg

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1
Deletion of in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice.在表达聚集蛋白聚糖的细胞中删除 会导致成年小鼠生长板软骨缺陷。
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2
Deletion of Axin1 in condylar chondrocytes leads to osteoarthritis-like phenotype in temporomandibular joint via activation of β-catenin and FGF signaling.髁突软骨细胞中的 Axin1 缺失通过激活β-catenin 和 FGF 信号导致颞下颌关节骨关节炎样表型。
J Cell Physiol. 2019 Feb;234(2):1720-1729. doi: 10.1002/jcp.27043. Epub 2018 Aug 2.
3
Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation.在成骨细胞前体细胞中抑制Axin1会通过抑制破骨细胞形成导致出生后骨骼生长缺陷。
Bone Res. 2020 Aug 12;8:31. doi: 10.1038/s41413-020-0104-5. eCollection 2020.
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ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo.ADAMTS-1基因敲除小鼠在体外或体内的蛋白聚糖周转方面未表现出异常。
Arthritis Rheum. 2005 May;52(5):1461-72. doi: 10.1002/art.21022.
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Aggrecan is required for growth plate cytoarchitecture and differentiation.软骨聚集蛋白聚糖是生长板细胞结构和分化所必需的。
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Specific deletion of leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice.特异性缺失 会导致 β-连环蛋白/BMP 信号通路的激活,从而导致小鼠出现腓骨半肢畸形表型。
Elife. 2022 Dec 21;11:e80013. doi: 10.7554/eLife.80013.
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A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate.一种用于研究哺乳动物生长板离散区域中聚集蛋白聚糖结构、生物合成和分解代谢的软骨外植体系统。
Matrix. 1993 Mar;13(2):135-47. doi: 10.1016/s0934-8832(11)80072-7.
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Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.肥大软骨细胞中溶酶体胞吐作用及聚集蛋白聚糖降解水解酶释放的证据,在体外用和体内。
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The biochemical characterization of aggrecan from normal and tibial-dyschondroplastic chicken growth-plate cartilage.正常和胫骨软骨发育不良鸡生长板软骨中聚集蛋白聚糖的生化特性
Biochem J. 2000 Oct 15;351 Pt 2(Pt 2):517-25.
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Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage.甲状腺激素可增强生长板软骨中聚集蛋白聚糖酶-2/ADAM-TS5的表达及蛋白聚糖的降解。
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引用本文的文献

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本文引用的文献

1
Deletion of Axin1 in condylar chondrocytes leads to osteoarthritis-like phenotype in temporomandibular joint via activation of β-catenin and FGF signaling.髁突软骨细胞中的 Axin1 缺失通过激活β-catenin 和 FGF 信号导致颞下颌关节骨关节炎样表型。
J Cell Physiol. 2019 Feb;234(2):1720-1729. doi: 10.1002/jcp.27043. Epub 2018 Aug 2.
2
BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.骨形态发生蛋白 2(BMP2),而非骨形态发生蛋白 4(BMP4),对于软骨细胞增殖和成熟,以及在软骨内骨发育过程中至关重要。
J Cell Sci. 2011 Oct 15;124(Pt 20):3428-40. doi: 10.1242/jcs.083659. Epub 2011 Oct 7.
3
Generation of Axin1 conditional mutant mice.
Axin1条件性突变小鼠的产生。
Genesis. 2011 Feb;49(2):98-102. doi: 10.1002/dvg.20703.
4
Developmental regulation of the growth plate.生长板的发育调控
Nature. 2003 May 15;423(6937):332-6. doi: 10.1038/nature01657.
5
The role of the resting zone in growth plate chondrogenesis.静止区在生长板软骨形成中的作用。
Endocrinology. 2002 May;143(5):1851-7. doi: 10.1210/endo.143.5.8776.